I use to have diabetes

Type 2 Diabetes, diet, microbiome

Summary:  Say you use to have Type 2 Diabetes.  How?  READ this study from ITALY.  Ma-Pi 2 diet for Type 2 Diabetes WORKED.  Type 2 Diabetes, diet, microbiome; the Ma-Pi 2 diet for Type 2 Diabetes is dietary modulation of microbiome.  Though this diet BEAT the current recommended diet by Italian professional societies (CTR) consider using it short term and supplementing the diet with healthy fat, wild caught fish, berries, and fermented dairy since the restriction of certain groups could lead to nutritional deficiencies especially vitamin B12 and calcium.   This study describes in pain staking detail, microbiome wise, microbiome impact.   Talk with your doctor for Ma-Pi 2 integration with therapy.  Managing the microbiome through diet is grassroots, and it works.   SAVE a friend and SHARE this post. That huge victory for Specific Carbohydrate Diet for the kids in Pittsburgh with IBD was grassroots.

Type 2 Diabetes, diet, microbiome
Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species

This is a major difference!  Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.

Ma-Pi 2 was more effective then CTR in reducing fasting and postprandial blood glucose, glycated Hb (HbA1c), serum cholesterol, homeostasis model assessment of insulin resistance (HOMA-IR), BMI and waist and hip circumferences compared with the CTR diet.

What is the Ma-Pi 2 Diet?

Ma-Pi 2 is complex carbohydrates, legumes, fermented products, sea salt and green tea, and it excludes fat and protein from animal source and added sugars.

I am posting this quickly to get the word out; if you find more links to exactly what the Ma-Pi 2 diet is, post it in the comments and I’ll update this post!

Updated 06/09/2016:  Preliminary research on what exactly is the MA-PI 2 diet gives pause; the restriction of certain groups could lead to nutritional deficiencies especially vitamin B12 and calcium.   Think about using Ma-Pi 2 short term and of supplementing the diet with healthy fat, wild caught fish, berries, and fermented dairy.  

Updated 10/23/2016:  The fat/carb loads are confusing.  The bottom line is that all calories are not alike.  Dr. Mark Hyman, Cleveland Clinic, has an incredible YouTube summary of the macronutrient balance for fat intake at  Why Fat Doesn’t Make You Fat!  Another favorite researcher is Dr. David Ludwig.  One of my favorite posts of Dr. Ludwig’s is at: Dr. David Ludwig clears up carbohydrate confusion. An important excerpt:  

… highly processed [refined grain, for example,] rice cereal [so much for those going gluten-free and choosing Cheerios] and table sugar may taste different, but below the neck they both cause metabolic problems.  The distinction between sugar and starch is largely meaningless from a biological perspective. The key public health challenge today is to reduce intake of all highly processed carbohydrates in favor of whole carbohydrates (fruits, vegetables, legumes and minimally processed grains) and healthful fats (like nuts, avocado and olive oil).

Choosing whole instead of highly processed carbohydrates will naturally result in a low GI diet that will also have many other nutritious aspects including high content of fiber, vitamins, minerals and polyphenols. (Note: Use of GI as a guide to food selection may have specific benefit for people with diabetes or other severe metabolic problems.)… For people with type 2 diabetes or related metabolic problems, very low carbohydrate diets including the ketogenic diet may offer an excellent long-term option. In some cases, a very low carbohydrate diet can reverse diabetes rapidly, without severe calorie deprivation. Much more research is needed into this area. But despite their potentially dramatic effects, very low carbohydrate diets can be difficult to maintain over the long-term. Replacing added sugars and refined starchy foods with unprocessed carbohydrate, healthful fats and proteins may provide many of the benefits of a very low carbohydrate diet, without having to eliminate an entire class of nutritious (and delicious) foods.

Updated 06/09/2016:  Notice the striking diet differences in Table 2 below.  Ma – Pi 2 has more than double CTR vegetable and seed intake.  Ma – Pi 2 vegetable and seed amount is ~66% compared to CTR at ~32%.  Additionally, the Ma – Pi 2 does not consume breads, cereal, pasta, grains, other starches, whole grains, and fruit whereas CTR does at ~42%.   Ma – Pi2 increases FIBER to 29gm compared to CTR.  Updated 10/23/2016: These are likely key to the beneficial alternations in microbiome as fiber substrates are PREBIOTICS, fuel for the microbiome having end result, of increasing short chain fatty acids.

Updated 06/09/2016:  Recall that Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.  Ma – Pi 2 does no fruit and therefore would be omitting antioxidants and phenol of berries which are anti-inflammatory.  Diet details are from supplemental data materials:

So in the end, are Ma- Pi 2 diet results due to switching off of the Western processed foods to a whole foods diet, an extreme form of detox from the Standard American Diet?  

The diet is a switch off of the Western diet with increased prebiotic, probiotic, and low toxin increased nutrient density that induce microbiome changes. You decrease consumption of certain gut microbiome inflammatory food but you substitute other food substrate having beneficial influence of an increased macrobiotic diet content that together,  have corresponding changes in the microbiome bacterial make-up of the gut.  Food switched off includes substrate ubiquitous  in the Western food system, such as emulsifiers, degrades the gut mucosal lining and are associated (in mice) with diabetes and metabolic syndrome.  Still, use it short term and supplement the diet with healthy fat (to absorb the fat soluble vitamins, see this post and this post), wild caught fish, berries, and fermented dairy.

Both diets modulated gut microbiome dysbioses increasing ecosystem diversity and supported the recovery of SCFA producers.

Both diets modulated gut microbiome dysbioses increasing ecosystem diversity and supported the recovery of a balanced community of health-promoting SCFA producers, such as Faecalibacterium, Roseburia, Lachnospira, Bacteroides and Akkermansia.

Here comes that great SCFA producer dietary blooming strategy again.  You’ve heard me mention it before and can refresh your understanding reading NICE, SCD INCREASED F. PRAUSNITZII… HUGH?!?

What is the CTR Diet?

The CTR diet derived energy from 40–60 % carbohydrate, 10–20 % protein, 30 % fat and ≥20 g/4184 kJ (1000 kcal) fibre. It was adapted to the Mediterranean culinary style. Vegetables, fruit, cereal, fish and white meat typical of the Mediterranean style were used; alcohol and sucrose consumption was forbidden. CTR is bread, cereal, pasta and grains, meats, eggs and meat broths, dairy products, fruit and fruit juice and extra-virgin olive oil.

Try Ma-Pi 2 and stop the cognition loss

For those details see HEARTBURN DRUGS, DEMENTIA, ALZHEIMER’S RISK FOR ALL? T2D, IS IT THE CANARY IN THE COAL MINE!?!

References

The open access study: Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet,

Also, for downloads, see this link.

Background on Type 2 Diabetes from Harvard Health Publications, New report provides a plan for living with type 2 diabetes

Type 2 diabetes use to be called adult-onset and non-insulin-dependent diabetes. It begins when muscle cells have trouble responding to insulin, a hormone that ushers glucose (blood sugar) into cells. Type 1 diabetes (formerly called juvenile-onset and insulin-dependent diabetes) is a different story. It occurs when the body’s immune system mistakenly attacks and damages insulin-making cells in the pancreas.

Type 2 diabetes accounts for about 90% of all cases of diabetes. It is also on the rise. Fifty years ago, about 1.6 million Americans had type 2 diabetes. Today, nearly 20 million have been diagnosed with it, and almost half again as many have type 2 diabetes but don’t know it.

Updated 10/23/2016:  To add:

The fat/carb loads are confusing.  The bottom line is that all calories are not alike.  Dr. Mark Hyman, Cleveland Clinic, has an incredible YouTube summary of the macronutrient balance for fat intake at  Why Fat Doesn’t Make You Fat!  Another favorite researcher is Dr. David Ludwig.  One of my favorite posts of Dr. Ludwig’s is at: Dr. David Ludwig clears up carbohydrate confusion. An important excerpt:  

… highly processed [refined grain, for example,] rice cereal [so much for those going gluten-free and choosing Cheerios] and table sugar may taste different, but below the neck they both cause metabolic problems.  The distinction between sugar and starch is largely meaningless from a biological perspective. The key public health challenge today is to reduce intake of all highly processed carbohydrates in favor of whole carbohydrates (fruits, vegetables, legumes and minimally processed grains) and healthful fats (like nuts, avocado and olive oil).

Choosing whole instead of highly processed carbohydrates will naturally result in a low GI diet that will also have many other nutritious aspects including high content of fiber, vitamins, minerals and polyphenols. (Note: Use of GI as a guide to food selection may have specific benefit for people with diabetes or other severe metabolic problems.)… For people with type 2 diabetes or related metabolic problems, very low carbohydrate diets including the ketogenic diet may offer an excellent long-term option. In some cases, a very low carbohydrate diet can reverse diabetes rapidly, without severe calorie deprivation. Much more research is needed into this area. But despite their potentially dramatic effects, very low carbohydrate diets can be difficult to maintain over the long-term. Replacing added sugars and refined starchy foods with unprocessed carbohydrate, healthful fats and proteins may provide many of the benefits of a very low carbohydrate diet, without having to eliminate an entire class of nutritious (and delicious) foods.

Also updated to highlight the importance of the increased fiber content of Ma-Pi2:   Ma – Pi2 increases FIBER to 29gm compared to CTR.  These are likely key to the beneficial alternations in microbiome as fiber substrates are PREBIOTICS, fuel for the microbiome having end result, of increasing short chain fatty acids. Last updated: October 23, 2016 at 10:03 am

Prior update 06/09/2016 dded precautions on use of Ma – Pi 2 and considerations for why it really may work.  The diet is a switch off of the Western diet with increased prebiotic, probiotic, and low toxin increased nutrient density that induce microbiome changes. You decrease consumption of certain gut microbiome inflammatory food but you substitute other food substrate having beneficial influence of an increased macrobiotic diet content that together,  have corresponding changes in the microbiome bacterial make-up of the gut.  Still, use it short term and supplement the diet with healthy fat (to absorb the fat soluble vitamins, see this post and this post), wild caught fish, berries, and fermented dairy.

Best in Health through Awareness!

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2 thoughts on “Type 2 Diabetes, diet, microbiome”

  1. The expert: David S. Ludwig, MD, PhD., May 29, 2016 FaceBook post: “I’m on the Endocrine inpatient service this weekend at Boston Children’s Hospital. My team and I admitted three teens with severe type 2 diabetes. These children suffer tragically from 1) a meltdown of their metabolism; 2) a breakdown of social structures that should support healthful eating among children – our most precious national resource.

    Type 2 Diabetes Mellitus in Children, Primary Care and Public Health Considerations http://jama.jamanetwork.com/article.aspx?articleid=194216 . http://bit.ly/24fFKJ0

  2. Thanks for the post of Ma-Pi 2 study, and the caution of sticking with it rigidly without fat, etc that will lead to other issues. The study, 153 pages is available on nih.gov when I googled the diet in the search box. Not read it yet. Appreciate you excitement and the caution.

Now I'd like to hear your thoughts... comments are always welcome!