I use to have diabetes

Type 2 Diabetes, diet, microbiome

Summary:  Say you use to have Type 2 Diabetes.  How?  READ this study from ITALY.  Ma-Pi 2 diet for Type 2 Diabetes WORKED.  Type 2 Diabetes, diet, microbiome; the Ma-Pi 2 diet for Type 2 Diabetes is dietary modulation of microbiome.  Although this diet BEAT the current recommended diet by Italian professional societies (CTR) consider using it short term and supplementing the diet similar to recommendations by Drs. Mark Hyman and David Ludwig noted below, with healthy fat, wild caught fish, berries, and fermented dairy (if tolerated), since the restriction of certain groups could lead to nutritional deficiencies especially vitamin B12 and calcium.   Actually, Dr. Hyman just offered his 10 Day Detox diet for FREE to the public that clarifies all the food recommended.  You can read about that at the post, JOIN DR. MARK HYMAN FREE 10 DAY DETOX CHALLENGE.  You may still be able to take advantage of this opportunity.  To clarify the carb loads for diabetes, Dr. Ruby Aujla’s Advice to Diabetes page (which is 100% in accord with Dr. Hyman’s 10 Day Detox) says,  Get your carbs from colorful plant based sources.  Even breakfast should be brimming with those!  Bread, White Rice, Pastas, White potato, Cereals (even cereals marketed as ‘wholegrain’), Instant Oats, Refined Grains, white potato are OUT.”  The Ma-Pi2 study describes in pain staking detail, microbiome wise, microbiome impact.   Talk with your doctor for Ma-Pi 2 integration with therapy.  Managing the microbiome through diet is new, grassroots, and it works.   SAVE a friend and SHARE this post. 

Type 2 Diabetes, diet, microbiome

Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species

This is a major difference!  Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.  You already know:  The foods you eat pre-selects your microbiome comunity!  Think of it as your microbial passengers seeing a lot of sugar from the boatload of starch and sugar you eat… those microbial passengers are looking for the missing antioxidants (from berries and EVOO for example), the missing phytonutrients and phytochemicals (from vegetables, fruits…), and etc.  Feed them what they need to flousish beneficially and you’ll see weight, waistline, and increased energy results!

Ma-Pi 2 was more effective then CTR in reducing fasting and postprandial blood glucose, glycated Hb (HbA1c), serum cholesterol, homeostasis model assessment of insulin resistance (HOMA-IR), BMI and waist and hip circumferences compared with the CTR diet.


What is the Ma-Pi 2 Diet?

Ma-Pi 2 is complex carbohydrates, legumes, fermented products, sea salt and green tea, and it excludes fat and protein from animal source and added sugars. 

My preliminary research on what exactly is the MA-PI 2 diet gives pause; the restriction of certain groups could lead to nutritional deficiencies especially vitamin B12 and calcium.   Think about using Ma-Pi 2 short term and of supplementing the diet with healthy fat, wild caught fish, berries, and fermented dairy similar to recommendations by Drs Mark Hyman and David Ludwig:  

Updated 10/23/2016:  The fat/carb loads are confusing.  The bottom line is that all calories are not alike.  Dr. Mark Hyman, Cleveland Clinic, has an incredible YouTube summary of the macronutrient balance for fat intake at  Why Fat Doesn’t Make You Fat!  Another favorite researcher is Dr. David Ludwig.  One of my favorite posts of Dr. Ludwig’s is at: Dr. David Ludwig clears up carbohydrate confusion. An important excerpt:  

… highly processed [refined grain, for example,] rice cereal [so much for those going gluten-free and choosing Cheerios] and table sugar may taste different, but below the neck they both cause metabolic problems.  The distinction between sugar and starch is largely meaningless from a biological perspective. The key public health challenge today is to reduce intake of all highly processed carbohydrates in favor of whole carbohydrates (fruits, vegetables, legumes and minimally processed grains) and healthful fats (like nuts, avocado and olive oil).

Choosing whole instead of highly processed carbohydrates will naturally result in a low GI diet that will also have many other nutritious aspects including high content of fiber, vitamins, minerals and polyphenols. (Note: Use of GI as a guide to food selection may have specific benefit for people with diabetes or other severe metabolic problems.)… For people with type 2 diabetes or related metabolic problems, very low carbohydrate diets including the ketogenic diet may offer an excellent long-term option. In some cases, a very low carbohydrate diet can reverse diabetes rapidly, without severe calorie deprivation. Much more research is needed into this area. But despite their potentially dramatic effects, very low carbohydrate diets can be difficult to maintain over the long-term. Replacing added sugars and refined starchy foods with unprocessed carbohydrate, healthful fats and proteins may provide many of the benefits of a very low carbohydrate diet, without having to eliminate an entire class of nutritious (and delicious) foods.

Notice the striking diet differences in Table 2 below.  Ma – Pi 2 has more than double CTR vegetable and seed intake.  Ma – Pi 2 vegetable and seed amount is ~66% compared to CTR at ~32%.  Additionally, the Ma – Pi 2 does not consume breads, cereal, pasta, grains, other starches, whole grains, and fruit whereas CTR does at ~42%.   Ma – Pi2 increases FIBER to 29gm compared to CTR.  Updated 10/23/2016: These are likely key to the beneficial alternations in microbiome as fiber substrates are PREBIOTICS, fuel for the microbiome having end result, of increasing short chain fatty acids.

Recall that Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.  Ma – Pi 2 does no fruit and therefore would be omitting antioxidants and phenol of berries which are anti-inflammatory.  Diet details are from supplemental data materials:

So in the end, are Ma- Pi 2 diet results due to switching off of the Western processed foods to a whole foods diet, an extreme form of detox from the Standard American Diet?  

The diet is a switch off of the Western diet with increased prebiotic, probiotic, and low toxin increased nutrient density that induce microbiome changes. You decrease consumption of certain gut microbiome inflammatory food but you substitute other food substrate having beneficial influence of an increased macrobiotic diet content that together,  have corresponding changes in the microbiome bacterial make-up of the gut.  Food switched off includes substrate ubiquitous  in the Western food system, such as emulsifiers, degrades the gut mucosal lining and are associated (in mice) with diabetes and metabolic syndrome.  Still, use it short term and supplement the diet with healthy fat (to absorb the fat soluble vitamins, see this post and this post), wild caught fish, berries, and fermented dairy – if tolerated, as recommended by Drs. Hyman and Ludwig.

Both diets modulated gut microbiome dysbioses increasing ecosystem diversity and supported the recovery of SCFA producers.

Both diets modulated gut microbiome dysbioses increasing ecosystem diversity and supported the recovery of a balanced community of health-promoting SCFA producers, such as Faecalibacterium, Roseburia, Lachnospira, Bacteroides and Akkermansia.

Here comes that great SCFA producer dietary blooming strategy again.  You’ve heard me mention it before and can refresh your understanding reading NICE, SCD INCREASED F. PRAUSNITZII… HUGH?!?


What is the CTR Diet?

The CTR diet derived energy from 40–60 % carbohydrate, 10–20 % protein, 30 % fat and ≥20 g/4184 kJ (1000 kcal) fibre. It was adapted to the Mediterranean culinary style. Vegetables, fruit, cereal, fish and white meat typical of the Mediterranean style were used; alcohol and sucrose consumption was forbidden.

CTR is bread, cereal, pasta and grains (but remember the above Ludwig excerpt that these cause metabolic problems below the neck because the body breaks them down to sugar – so the distinction between sugar and starch below the neck is largely meaningless from a biological perspective), meats, eggs and meat broths, dairy products, fruit and fruit juice and extra-virgin olive oil.


Try Ma-Pi 2 (modified to include Drs. Hyman and Ludwig recommendations) and stop the cognition loss!

For those details see HEARTBURN DRUGS, DEMENTIA, ALZHEIMER’S RISK FOR ALL? T2D, IS IT THE CANARY IN THE COAL MINE!?!


References

The open access study: Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet,

Also, for downloads, see this link.


Background on Type 2 Diabetes from Harvard Health Publications, New report provides a plan for living with type 2 diabetes

Type 2 diabetes use to be called adult-onset and non-insulin-dependent diabetes. It begins when muscle cells have trouble responding to insulin, a hormone that ushers glucose (blood sugar) into cells. Type 1 diabetes (formerly called juvenile-onset and insulin-dependent diabetes) is a different story. It occurs when the body’s immune system mistakenly attacks and damages insulin-making cells in the pancreas.

Type 2 diabetes accounts for about 90% of all cases of diabetes. It is also on the rise. Fifty years ago, about 1.6 million Americans had type 2 diabetes. Today, nearly 20 million have been diagnosed with it, & almost half again as many have type 2 diabetes but don’t know it.


Conclusion:  Look over those diets discussed in this post and understand the foods you consume pre-selects your microbiome, which determines metabolism and health.  The Ma-Pi2 study describes in pain staking detail, microbiome wise, microbiome impact.

Best in Health through Awareness!

Signature2

 

Last updated: June 3, 2017 at 6:52 am for easier read bc this post gets a lot of hits.  

Added to “Summary”:  Actually, Dr. Hyman just offered his 10 Day Detox diet for FREE to the public that clarifies all the food recommended.  You can read about that at the post, JOIN DR. MARK HYMAN FREE 10 DAY DETOX CHALLENGE.  You may still be able to take advantage of this opportunity.  To clarify the carb loads for diabetes, Dr. Ruby Aujla’s Advice to Diabetes page (which is 100% in accord with Dr. Hyman’s 10 Day Detox) says,  “Get your carbs from colorful plant based sources.  Even breakfast should be brimming with those!  Bread, White Rice, Pastas, White potato, Cereals (even cereals marketed as ‘wholegrain’), Instant Oats, Refined Grains, white potato are OUT.”

Ma-Pi 2, but NOT the CTR, counteracted increase of possible pro-inflammatory microbiome species”:  You already know:  The foods you eat pre-selects your microbiome comunity!  Think of it as your microbial passengers seeing a lot of sugar from the boatload of starch and sugar you eat… those microbial passengers are looking for the missing antioxidants (from berries and EVOO for example), the missing phytonutrients and phytochemicals (from vegetables, fruits…), and etc.  Feed them what they need to flousish beneficially and you’ll see weight, waistline, and increased energy results!

Added to “What is the CTR Diet”:  (but remember the above Ludwig excerpt that these cause metabolic problems below the neck because the body breaks them down to sugar – so the distinction between sugar and starch below the neck is largely meaningless from a biological perspective),

Added:  Conclusion:  Look over those diets discussed in this post and understand the foods you consume pre-selects your microbiome, which determines metabolism and health.  The Ma-Pi2 study describes in pain staking detail, microbiome wise, microbiome impact.

Deleted: I am posting this quickly to get the word out; if you find more links to exactly what the Ma-Pi 2 diet is, post it in the comments and I’ll update this post!


Prior update 10/23/2016:  

The fat/carb loads are confusing.  The bottom line is that all calories are not alike.  Dr. Mark Hyman, Cleveland Clinic, has an incredible YouTube summary of the macronutrient balance for fat intake at  Why Fat Doesn’t Make You Fat!  Another favorite researcher is Dr. David Ludwig.  One of my favorite posts of Dr. Ludwig’s is at: Dr. David Ludwig clears up carbohydrate confusion. An important excerpt:  

… highly processed [refined grain, for example,] rice cereal [so much for those going gluten-free and choosing Cheerios] and table sugar may taste different, but below the neck they both cause metabolic problems.  The distinction between sugar and starch is largely meaningless from a biological perspective. The key public health challenge today is to reduce intake of all highly processed carbohydrates in favor of whole carbohydrates (fruits, vegetables, legumes and minimally processed grains) and healthful fats (like nuts, avocado and olive oil).

Choosing whole instead of highly processed carbohydrates will naturally result in a low GI diet that will also have many other nutritious aspects including high content of fiber, vitamins, minerals and polyphenols. (Note: Use of GI as a guide to food selection may have specific benefit for people with diabetes or other severe metabolic problems.)… For people with type 2 diabetes or related metabolic problems, very low carbohydrate diets including the ketogenic diet may offer an excellent long-term option. In some cases, a very low carbohydrate diet can reverse diabetes rapidly, without severe calorie deprivation. Much more research is needed into this area. But despite their potentially dramatic effects, very low carbohydrate diets can be difficult to maintain over the long-term. Replacing added sugars and refined starchy foods with unprocessed carbohydrate, healthful fats and proteins may provide many of the benefits of a very low carbohydrate diet, without having to eliminate an entire class of nutritious (and delicious) foods.

Also updated to highlight the importance of the increased fiber content of Ma-Pi2:   Ma – Pi2 increases FIBER to 29gm compared to CTR.  These are likely key to the beneficial alternations in microbiome as fiber substrates are PREBIOTICS, fuel for the microbiome having end result, of increasing short chain fatty acids. Last updated: June 3, 2017 at 6:52 am


Prior update 06/09/2016 added precautions on use of Ma – Pi 2 and considerations for why it really may work.  The diet is a switch off of the Western diet with increased prebiotic, probiotic, and low toxin increased nutrient density that induce microbiome changes. You decrease consumption of certain gut microbiome inflammatory food but you substitute other food substrate having beneficial influence of an increased macrobiotic diet content that together,  have corresponding changes in the microbiome bacterial make-up of the gut.  Still, use it short term and supplement the diet with healthy fat (to absorb the fat soluble vitamins, see this post and this post), wild caught fish, berries, and fermented dairy.

 

4 thoughts on “Type 2 Diabetes, diet, microbiome”

  1. GUT MICROBIOTA & DIABETES. A selection of content from the Gut Microbiota for Health. Experts Exchange 2015. January 2016
    http://www.gutmicrobiotaforhealth.com/wp-content/uploads/2016/04/GMFHx-BestOf-GMDiabetes2015.pdf

    The role of microbiome in T2D and weight: Loaded report including functional metabolite differences and dietary novel treatments that address the microbiome. Bottom line: To combat T2D, you cannot ignore fixing the microbiome. Just a few of the studies included and attached: Dao, et al. showed for the first time that NOT all obese subjects have equal potential for weight loss-induced improvement of metabolic disorders when they adopt a calorie restriction diet. These researchers linked the presence of Akkermansia muciniphila with a more beneficial response to calorie restriction dietary intervention. Delzenne et al. focuses on the role of specific nutrients on the gut microbiota composition: prebiotics (inulin-type fructans), arabinoxylans, and polyphenols. Le Barz found that microorganisms can fight the gut microbiota dysbiosis that is frequently associated with metabolic disorders in humans:
    – There is no “universal strain” of probiotics that alone provides all the benefits associated with probiotics; rather, probiotic effects are often strain-specific
    – Probiotics can act by (1) restoring the disrupted intestinal barrier and therefore reducing endotoxemia, (2) producing short-chain fatty acids such as butyrate, or (3) decreasing lowgrade
    inflammation
    – Prebiotics can enhance the functionality of probiotics.
    So MANY more Pearls… anyone concerned with metabolic, weight, obesity needs to read the report!

  2. The expert: David S. Ludwig, MD, PhD., May 29, 2016 FaceBook post: “I’m on the Endocrine inpatient service this weekend at Boston Children’s Hospital. My team and I admitted three teens with severe type 2 diabetes. These children suffer tragically from 1) a meltdown of their metabolism; 2) a breakdown of social structures that should support healthful eating among children – our most precious national resource.

    Type 2 Diabetes Mellitus in Children, Primary Care and Public Health Considerations http://jama.jamanetwork.com/article.aspx?articleid=194216 . http://bit.ly/24fFKJ0

  3. Thanks for the post of Ma-Pi 2 study, and the caution of sticking with it rigidly without fat, etc that will lead to other issues. The study, 153 pages is available on nih.gov when I googled the diet in the search box. Not read it yet. Appreciate you excitement and the caution.

    1. Thank you for your comment! Dr. Hyman just offered his 10 Day Detox program FREE to the public, and it is very similar to what is explained above (modifying the Ma-PI 2 to include the Drs Hyman and Ludwig recommendations). You can read about that in the post, Join Dr. Mark Hyman FREE 10 DAY DETOX Challenge, http://biomeonboardawareness.com/join-dr-mark-hyman-free-10-day-detox-challenge/. He added in many helpful downloads. Hoping you were able to jump onboard that opportunity or perhaps to still take advantage of it!

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