SUMMARY: Imagine a home test differentiating between Irritable Bowel Syndrome (IBS) and autoimmune Inflammatory Bowel Disease (IBD)! The time is nearing… IBdoc is a cheap easy to use home test that measures gut inflammation and presently is used in Europe. It is still 2 to 3 years away from FDA approval in the US, but clinical trial recruitment has begun; make the call and participate (see below for details.) The device finds gut inflammation before relapse or flare: actually 3 months ahead of IBD relapse giving you (and your physician) time to address such. The device hopefully too will be found capable of differentiating between IBD versus IBS. Update: tweeted from 11th Congress of ECCO March 16-19, 2016 presentation: fecal calprotectin rises 4 months before flares.
Category Archives: Blog: Clinical Trials-Diet/Environment/Disease
A professional autism dietary intervention program.
Summary: It is time to share what a successful professional autism dietary intervention program can look like for autism management.
“Special Diets and Nutrition For Autism: Why They’re Cost Effective,” is such an interesting read from Judy Converse MPH RD LD, a registered dietitian since 1989, who then self taught herself, beginning in 1996, diet impact for her son’s growth, feeding, and developmental challenges at birth. She then expanded training to learn biomedical intervention for autism, becoming a DAN practitioner, and ultimately provided instruction in nutrition for Autism Research Institute, US Autism and Aspergers Assocation, National Autism Association, and many others. She has lectured for many local and national audiences about the profound impact nutrition and a healthy gut have on the developing brain as well as authoring three books and created the first web-interface accredited learning module for health care providers on nutrition and autism in 2007.
Alzheimer’s Diet, Microbiome, & Bio-marker Predictors
SUMMARY: Learn the latest on Alzheimer’s Diet, Microbiome, & Bio-marker Predictors. Such is welcome news as the latest Alzheimer’s Facts & Figures show that over 5 million Americans are living with Alzheimer’s, including an estimated 200,000 under the age of 65.
By 2050, the number of people age 65 and older with Alzheimer’s disease may nearly triple, from 5 million to as many as 16 million. Truly, Alzheimer’s is one of the diseases most feared in my talks; it is the sixth-leading cause of death in the United States. The estimate is that by age 64, one in 8 will have Alzheimer’s. That rate doubles every 5 years. So by age 70, one in 4 will have Alzheimer’s. And by age 75, one in 2 will have Alzheimer’s. These stats are from a 2013 interview of Dr. Thomas Wisniewski, @ time 25:30: “Brains – The Latest Research 07/01/2013 – 08:04” (NYU Langone Medical Center Audiocast, SirusXM Dr. Radio programming), who’s lab, Dr. Thomas Wisniewski’s Lab, is one of the leading Alzheimer research labs.
Autism Microbiome Study: 2 Studies Seek Participants
The 1st major funded Autism Microbiome Study:
“Autism Speaks Invests $2.3 Million in Research on Autism Gut-Brain Connection,“ which makes these studies the first major funded GI initiative that investigates microbiome, biological stress and bowel disorder treatment in children with autism.
Clinical trials will span 3 years and are now filling if you are interested. Please share this information on Facebook, Twitter, Pinterest… so that others can participate. While this research might be a decade or so behind what parents know, it’s two decades ahead of our GP and many autism treatment facilities, so it’s needed, it’s important, and I’m very grateful to hear about it.
Microbirth: Health Ramifications associated with C-Section birth
SUMMARY: Learn the long term health ramifications associated with C-Section birth. “Microbirth” information every parent needs to view.
“Microbirth“ is a new 60 minute documentary investigating the latest scientific research about the microscopic events happening during childbirth. As this Press Release explains, latest research is starting to indicate modern birth practices could be interfering with critical biological processes. From the changes that occur in the human pregnant vaginal microbiome to that microbiome which actually inoculates the baby, be it via C-section or vagina birth, these events are now showing to have associated consequences for the health of the child and such could have life-long consequences making our children more susceptible to disease later in life:
Clinical Trials Lack Diversity & Microbiome = Cancer Disparity Outcomes
Under representation of minority populations in clinical trials is a real problem, and it results in significant cancer outcome disparities for under represented groups (discussed at the bottom of this post). What this means is that the findings of clinical trials are limited and can not necessarily be generalized among those minorities under represented or omitted in the study population. Such subgroups are missing information on how they would respond to the trial’s treatment. “Potential racial, ethnic and other differences in response to drugs are important to FDA’s efforts to help ensure that the safety and effectiveness of drugs are studied in all people who will use the products once they are approved.” Christine Merenda, M.P.H., R.N. , Office of Minority Health (OMH) project manager.
1st Study: Low Dose BPA Perinatal Exposure & Food Intolerance
There has been a lot of recent discussion about BPA, especially as it affects infants. Now we see for the first time, that low dose BPA perinatal exposure is associated with food intolerance, specifically the egg white protein, at least for rats. Remember the alternative, BPS, is even less studied and some say it is worse than BPA.
This January 2014 study, showed that BPA is in both breast milk and newborn and infant urines regardless if breastfed or formula fed. “RESULTS: Total BPA was detected in 93 % of urine samples in this healthy infant population aged 3-15 months who were without known environmental exposure to BPA . Similarly, 75 % of the mothers’ breast milk samples had detectable concentrations of total BPA.”
Delivery & BreastFeed Studies & Newborn Microbiome Manipulation
Summary: Newborn microbiome differs by mode of delivery and feeding. Newborn C-section microbiome: Swabbing C-section babies partially restores the newborn microbiome.
First, a quick refresher of “How we acquire our gut microbiome.“
Our gut microbiome is acquired at birth, though this is by no means a simple answer. The post “Newborn Gut Microbiome Begins at Birth” details many differences between the newborn gut microbiome due to mode of delivery (vaginal versus C-Section) as well as feeding (breast-fed versus formula-fed). The figure below extends this and shows the recent findings that the developing microbiome is shaped not only by delivery and feeding mode, but that antibiotics, probiotics, and environmental exposures also interact and develops the newborn’s microbiome and resultant immune system.
Food Managing IBD & AUTISM: The Studies
SUMMARY: Anytime food choices turns around chronic disease with studies that prove such, that should be an eye opener! Implementing principles of such diets should be considered for anyone wanting to prevent or manage chronic disease. This post presents studies for Food Managing IBD & AUTISM, where dietary protocols achieved remission and management (with reduction, if not elimination of medication) for autoimmune IBD , or positively altered the course of autism.
HOW? Diet can optimize (or modulate) the gut microbiome which is the source of 80 – 85 percent of our immunity:
The “1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism,” July 2014: “the microbiome refers to the constellation of enteric bacteria that create an organ system that makes up 80% of our immune system...“
Testing if calories trigger hormones that regulate fat cell behavior
Summary: NUSI is now testing if calories trigger hormones that regulate fat cell behavior. This will help answer the question of which camp we should we be in, namely: the sugar is bad/saturated fat is the good camp versus the whole grain/low fat is the good camp.
Enter NUSI → Seems bad science got us into the mess and state of confusion and ignorance. So Gary Tuabes has aligned with Dr. Peter Attia, MD to do “good science“ and answer the age old question: Do we get fat because we eat too much and especially too much fat OR is it the food we eat, especially the increased consumption of table sugar and other refined carbohydrates the likely explanation for our current chronic disease epidemic including obesity? There’s a real difference there, honest!