Category Archives: Blog: Clinical Trials-Diet/Environment/Disease

1st Study: Low Dose BPA Perinatal Exposure & Food Intolerance

There has been a lot of recent discussion about BPA, especially as it affects infants.  Now we see for the first time, that low dose BPA perinatal exposure is associated with food intolerance, specifically the egg white protein, at least for rats.  Remember the alternative, BPS, is even less studied and some say it is worse than BPA.

This January 2014 study, showed that BPA is in both breast milk and newborn and infant urines regardless if breastfed or formula fed. “RESULTS:  Total BPA was detected in 93 % of urine samples in this healthy infant population aged 3-15 months who were without known environmental exposure to BPA . Similarly, 75 % of the mothers’ breast milk samples had detectable concentrations of total BPA.”

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Delivery & BreastFeed Studies & Newborn Microbiome Manipulation

Summary: Newborn microbiome differs by mode of delivery and feeding.  Newborn C-section microbiome:  Swabbing C-section babies partially restores the newborn microbiome.
First, a quick refresher of “How we acquire our gut microbiome.

Our gut microbiome is acquired at birth, though this is by no means a simple answer.  The post “Newborn Gut Microbiome Begins at Birth”  details many differences between the newborn gut microbiome  due to mode of delivery (vaginal versus C-Section) as well as feeding (breast-fed versus formula-fed).  The figure below extends this and shows the recent findings that the developing microbiome is shaped not only by delivery and feeding mode, but that antibiotics, probiotics, and environmental exposures also interact and develops the newborn’s microbiome and resultant immune system.

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Food Managing IBD & AUTISM: The Studies

SUMMARY:  Anytime food choices turns around chronic disease with studies that prove such, that should be an eye opener!  Implementing principles of such diets should be considered for anyone wanting to prevent or manage chronic disease.  This post presents studies for Food Managing IBD & AUTISM, where dietary protocols achieved remission and management (with reduction, if not elimination of medication) for autoimmune IBD , or positively altered the course of autism.

HOW?  Diet can optimize (or modulate) the gut microbiome which is the source of 80 – 85 percent of our immunity:  

The “1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism,” July 2014: “the microbiome refers to the constellation of enteric bacteria that create an organ system that makes up 80% of our immune system...

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Testing if calories trigger hormones that regulate fat cell behavior

Summary:  NUSI is now testing if calories trigger hormones that regulate fat cell behavior.  This will help answer the question of  which camp we should we be in, namely:  the sugar is  bad/saturated fat is the good camp versus the whole grain/low fat is the good camp. 

Enter NUSI →   Seems bad science got us into the mess and state of confusion and ignorance.  So Gary Tuabes has aligned with Dr. Peter Attia, MD to do good science and answer the age old question:  Do we get fat because we eat too much and especially too much fat OR is it the food we eat, especially the increased consumption of table sugar and other refined carbohydrates the likely explanation for our current chronic disease epidemic including obesity?  There’s a real difference there, honest!

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Arthritis Microbiome & Gut Health: Diet

Summary:  Arthritis… Newly diagnosed with arthritis have an arthritis microbiome that is skewed having greater abundance of the intestinal bacteria Prevotella copri than people without the inflammatory disease, or those who have had the disease for a while but were managing it with treatment. Also found: nutrient deficiencies.  Diet can change up that microbiome.  Read on and learn.

One of the first insightful articles that expanded my understanding of the connection between gut microbiome, dietary impact, and arthritis, was “The Boy With a Thorn in His Joints,” New York Times Magazine, February 2001.  Anywhere from 0.5 to 1 percent of the general population is estimated to have the condition, according to the Centers for Disease Control and Prevention.  If you are a reader of my work, you now know however, it isn’t just arthritis that the gut biome affects; literally all health and disease is affected by the gut microbiome, specifically the community of species present.

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FEED YOUR MICROBIOME TO MANAGE AUTISM

Microbiome and autism…  Feeding your gut microbiome could exacerbate, or modulate, autism symptoms.  That understanding is incredibly empowering to those that must manage autism!

It is now undisputed that the gut microbiome differs in autism compared to healthy controls:

“At the annual meeting of the American Society for Microbiology held in May in Boston, researchers at Arizona State University reported the results of an experiment in which they measured the levels of various microbial by-products in the feces of children with autism and compared them with those found in healthy children. The levels of 50 of these substances, they found, significantly differed between the two groups. And in a 2013 study published in PLOS ONE, Italian researchers reported that, compared with healthy kids, those with autism had altered levels of several intestinal bacterial species, including fewer Bifidobacterium, a group known to promote good intestinal health.”  “Gut Bacteria May Play a Role in Autism”, Scientific American, Aug 2014.  

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SCD Managing IBD, RUSH Medical Center

SCD managing IBD is nothing new.   RUSH University Medical Center, Chicago is one facility that extensively studies SCD and IBD.

I am now aware of two studies RUSH  intends to publish by the end of 2014. The first is to identify “characteristics common for those for whom SCD works to manage IBD.”  My contact was not allowed to share at this time what the second study’s content will be.

RUSH is not alone however in the study of SCD and IBD; I have written extensively on the science of SCD success here:

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MICROBIOME RULES; WHAT IS MICROBIOME?

SUMMARY:  Your gut microbiome allows you to live your life with health, wellness, and vitality, or illness and disease.  Without a doubt, the MICROBIOME RULES; WHAT IS MICROBIOME?

If you haven’t already done so, you should read the post, “Diet and other things Determines Our Microbiome” to be certain you are up to date not only with what this dynamic virtual organ is, but also are cognizant of the many factors that affect the microbiome.  
We can modulate this microbiome; the science is exploding daily with research that is unveiling the vast impact the gut microbiome has on all of our inner workings.
FOOD ALTERS THE MICROBIOME, with a focus here on celiac and autism, although the insight applies to all autoimmunes and chronic disease.

The post “Food Managing Autism and IBD: The Studies,” details the studies (and includes current ongoing clinical trials) showing dietary intervention (that heals the gut) can result in IBD remission or management of autism.  Such occurs through optimization of the microbiome since the food we feed the microbiome, determines the gut’s community of microbiota, whose role is to affect immunity, health, wellness, and vitality.  Thus, anyone looking to improve health needs to look first at optimizing the gut microbiome.

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