Last Updated on January 19, 2024 by Patricia Carter

SUMMARY: Bone Broth is a traditional food that has been on dinner tables for ages, and yet it has nearly disappeared from the American table. I spent years researching what’s in Bone Broth, and why I should make it for my family. After all, it seemed to be loaded with hidden dangers like the potential for lead leaching into the Bone Broth from the slow cooker vessel and the animal bones themselves, histamine reactions due to its long cook, and even contrary to what other bloggers write, the TRUTH is that the evidence finds there’s NOT a huge mineral load in Bone Broth. After reading loads of studies, I decided to post this BRIEF FREE summary of what I found because the evidence proved to me that there are many components in Bone Broth that makes it worthwhile to make. I now do so as do leading functional medicine doctors like Cleveland Clinic Health Essentials, Dr. Mark Hyman, and Dr. Kara Fitzgerald. You can also read here how bone broth is being used during fast just prior to cancer immunotherapy to improve outcomes for insulin resistant related type cancers (breast, colorectal cancer, endometrial cancer, pancreatic cancer, glioblastoma multiforme).

This post is kept short because it mainly shares my Bone Broth Recipe showing you how we make Bone Broth as nutrient and gelatin/collagen rich as safely as possible. If you want more details, consider purchasing our Bone Broth Workshop book provided to participants in the Bone Broth Workshop. There you’ll learn the difference between Bone Broth vs collagen, an important distinction.

Simply put, Bone Broth contains gelatin which is the cooked dietary source of collagen. However, the MORE EASILY ABSORBED FORM of collagen with documented health benefits is called COLLAGEN HYDROLYSATE, and that can be purchased as a powder for supplement!!! Studies find 90% of collagen hydrolysate’s amino acids get absorbed in the small intestine, and those supports joint, bone, muscle, skin, blood sugar, sleep, digestion, and even potentially microbiome health. That’s important since our collagen production DECREASES as we AGE (we LOSE about 1.5% per year after age 20), and autoimmune diseases, ageing, and stress impairs collagen quality. Simply put, collagen proteins are building compounds that integrate into human tissue.

Now you see the purpose of this post –> it is imperative to maintain, support, and boost our collagen targeting as many strategies as possible! Intrigued? Read on to learn more including why/how we use Great Lakes Collagen Hydrolysate for our collagen supplement (they have been a collagen wellness leader since 1922) and why we agreed to be an affiliate. In addition, give our Bone Broth recipe a try! Let us know your experiences by tagging us on Instagram, or direct message us here!

Just to clarify, as used in this article, Collagen Hydrolysate, Collagen Protein, Collagen Peptides and Hydrolyzed Collagen Peptides are all the same.

First up, the Bone Broth Recipe!

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To learn LOADS MORE than this post about Bone Broth, Collagen, and Collagen Hydrolysate –> Consider Purchasing our Bone Broth Workshop BOOK \O/

Our Bone Broth Workshop book is provided to participants in our Workshop. It dives deep into what is Bone Broth, gelatin, collagen, and collagen hydrolysate and their nuances. It covers: what nutrients are in Bone Broth and which vegetables to use to increase nutrients in both Bone Broth AND in recipes that uses the broth. It shows how to source “clean” bones, what cooking vessels help keep the lead out of bone broth, how much to drink, how to make it for pennies (important because the few commercially available decent options are north of $16 for the quantity you’ll make using this recipe), and how to practically integrate Bone Broth into your diet. Last, it provides links to the science on gelatin, collagen, and collagen hydrolysate benefit for joint, skin, and microbiome. If you want to dive even deeper with more links covering collagen hydrolysate benefit for digestion, blood sugar, bone, muscle, sleep, and sarcopenia, contact us here for the CME version.

Heavy Metal Test Results –>

With collagen powder supplement increasing due to consumer, healthcare and medical sector awareness of benefits, we also share important heavy metal test results for many collagen supplements. Here is one article showing collgen toxin and heavy metal safety profile for many popular brands you may choose to steer clear of! I’m happy Great Lakes Wellness collagen products are a BEST PICK!!! Ingredient quality, amino acid profile, and toxin and heavy metal safety profile for Great Lakes Collagen Hydrolysate is the reason why we use this supplement and agreed to be an affiliate. Purchase it here; for best pricing buy bulk!

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Guys, remember why we’re learning all of this –>

Collagen Basics

• Collagen is the most abundant protein in the human body — About one quarter of all of the protein in your body is collagen. [Deane et al 2020]
  1. We make collagen from amino acids glycine, proline, lysine, and leucine – with the help of vitamin C, zinc, manganese, and copper. [Warwick 2020] Each chain is over 1400 amino acids long. Every third amino acid in collagen is glycine and many of the other positions are filled with proline and hydroxyproline. [NIH Vitamin C Fact Sheet for Professionals]
  2. There are 28 known different types of collagen, but Types I, II, and III comprise about 90% of what is found in the human body. It is particularly concentrated in skin, tendons, cartilage, bone, blood vessels, and cornea. Bones and teeth are made by adding mineral crystals to collagen. [CHCompendium, pages 8– 9] You may also be able to access this report at https://lknlife.es/assets/files/Collagen%20report.pdf
  3. Collagen forms molecular cables that strengthen our tendons and resilient sheets that support our skin and internal organs giving our bones, organs, skin and connective tissue shape, flexibility and strength. It is a vital structural matrix component throughout almost all tissues and organs of the body. It is collagen’s sturdy tightly wound triple chain protein helix structure of special amino acids that makes the molecule particularly stable and gives structure to our body, protecting and supporting the softer tissues and connecting them with the skeleton. [PDB-101, Molecule of the Month: Collagen] 
  4. Collagen is the uncooked form of gelatin. The body can’t absorb collagen in whole form. The collagen protein must be broken down during the cooking process and digestive process before absorption into the bloodstream. Gelatin is the cooked dietary source of collagen. The MORE EASILY ABSORBED FORM of collagen, with PUBMED studies supporting loads of health benefit, is called COLLAGEN HYDROLYSATE. [Santa Cruz 2019][Sibilla et al 2015] 

• THIS –> It is imperative that we maintain, support, and boost our collagen because our collagen production DECREASES as we AGE (we LOSE about 1.5% per year after age 20), and autoimmune diseases, ageing and stress impairs collagen quality. [Sibilla et al 2015] [Obagi, Scientific American 2005]
• THIS –> 90% of the small collagen hydrolysate peptides (amino acids produced with digestion) gets absorbed in the small intestine. These free amino acids get distributed throughout our body by our network of blood vessels. These proteins are building compounds that integrate into human tissue.

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Some KEY PUBMED study findings –>

Degenerative joint and bone diseases such as osteoarthritis and osteoporosis.

• For JOINT HEALTH –> Collagen hydrolysate supplementation decreased pain and increased the proteoglycan content in knee cartilage after 6 months of treatment in osteoarthritis patients. [Jiang et al 2014]
• For JOINT HEALTH –>  Type II collagen significantly improved overall joint osteroarthritis symptoms measured by the change in WOMAC total score after only 4 weeks in a randomized double blind placebo controlled trial. [Luo et al 2022]
• For JOINT HEALTH –> A systematic review published in 2021 in Amino Acids found that 5-15 grams of collagen peptide supplementation per day improved joint pain and functionality in athletes, with the best results observed in elderly participant. [Khatri et al 2021]
• For BONE HEALTH –> Collagen-enriched serum beneficially impacted bone cell activity. It enhanced osteoblast activity supporting bone formation, while also lowering osteoclastogenesis which is responsible for the degradation of bone cells in human cell lines. [Wauquier et al 2019]

Body Composition and Muscle Strength

• Background. No matter your age or sex, we all need skeletal muscle mass for health, longevity and just saying, we look good wearing it! Muscle mass accounts for about 35% of total body weight and plays an essential role in glucose metabolism, endocrine function, thermogenesis, and movement. Loss of muscle mass increases the risk of chronic degenerative diseases of the metabolism like type II diabetes mellitus and increases the risk of orthopedic-accident surgery due to falls.
  • Increasing age is associated with a decrease in muscle mass and function.
  • Between 25–50% of adults over the age of 60 years have sarcopenia.
• Randomized controlled trials found that collagen peptide ingestion with resistance training increased muscle strength and fat-free mass with decreased fat mass in pre-menopausal women and older men having sarcopenia. [Jendricke et al 2019] [Zdzieblik et al 2015], respectively.
• Important [Jendricke et al 2019] excerpts:

Dietary protein supplementation is an effective strategy for improving strength gains and muscle mass during prolonged resistance exercise in younger and older people.

Resistance training (high loads) are necessary to induce beneficial changes in muscle mass and strength. By activating the skeletal muscle protein synthesis, resistance exercise improves muscle protein balance. The mammalian target of rapamycin (mTOR) is generally considered an important regulator of protein synthesis and cell growth.

Collagen Hydrolysate seems to have signaling properties that activates the mTOR signaling pathway. The mTOR complex is activated by arginine and glycine. Collagen peptides show a high arginine and especially glycine content. These amino acids might stimulate mTOR signaling as seen in cell culture studies.

[Zdzieblik et al 2017] looked at dosing 10, 15, versus 20 gms of collagen peptides and found the optimal recommended daily post exercise intake to be 15 gm for increased fat free mass and reduced fat mass.

Skin

• Young skin is made by 80% Type I collagen and about 15% collagen Type III. The ability to replenish these naturally decreases with age, about 1.5% per year. Orally ingested small collagen peptides and free amino acids get distributed throughout our body by our network of blood vessels, and in particular they reach the dermis, where it has been proven they can remain up to 14 days! This improved skin suppleness and softness that even ironed out wrinkles! [Sibilla et al 2015] [Obagi, Scientific American 2005]
• A 2021 Systemic Review and Meta Analysis of several clinical studies published in the International Journal of Dermatology concluded that taking hydrolyzed collagen for 90 days can be effective in visibly improving the appearance of wrinkles, skin elasticity, and skin hydration. [Miranda et al 2021] Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis, https://pubmed.ncbi.nlm.nih.gov/33742704/

Microbiome Impact

• Cutting edge lead researchers are exploring the concept that joint protective nutraceuticals like collagen may exert their beneficial influence via shifts in thegut microbiome with mitigation of disease, their focus being osteoarthritis! [Favazzo et al 2020]Makes us wonder –> will it help with other microbiome related diseases?!! KEY points of their work are:
  1. Gut dsybiosis contributes to the development of osteoarthritis.
  2. Shifts in gut microbiome composition may reduce progression of osteoarthritis.
  3. The microbiome can be an emerging target for osteoarthritis therapeutics.
  4. Joint protective nutraceuticals (including collagen hydrolysate) may exert their influence via shifts in the gut microbiome, possibly acting as a prebiotic.
• That collagen hydrolysate may affect the gut microbiome as a prebiotic is a revolutionary thought. If true, [Favazzo et al 2020] authors suggest that many more diseases associated with gut dsybiosis may positively be effected with collagen hydrolysate supplementation. To bring home the importance of this thought, the authors list a few diseases known to have established shifts in microbiome:
  1. Amyotrophic Lateral Sclerosis,
  2. Parkinson’s Disease,
  3. Alzheimer’s Disease,
  4. Rheumatoid Arthritis,
  5. Crohn’s Disease,
  6. Type 2 Diabetes,
  7. Metabolic Syndrome ,
  8. Osteoporosis

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Now that we have your attention, HERE’s a CHECKLIST for HOW WE CAN INCREASE COLLAGEN

1. EAT A NUTRITION DIET THAT SUPPORTS COLLAGEN PRECURSOR NEEDS. We make collagen, the most abundant protein in your body, from amino acids glycine, proline, lysine, and leucine with the help of vitamin C, zinc, manganese, and copper. [Warwick 2020] 
2. CONSUME KEY AMINO ACID (including proline, glycine, lysine, and leucine), or combinations thereof, ALONG WITH EXERCISE, to support formation of collagen in ligaments and tendons. [Alcock et al 2019]
3. CONSUME GELATIN-RICH BONE BROTH to increase your collagen stores. Bone Broth is made from cooking collagen that is contained in animal skin, bone, ligaments, and/or tendons and in fish skins, bones, and fins. When these parts are heated, the collagen breaks down and loses all of its structure. The triple helix unwinds and the chains separate. Then, when this tangled mass of chains cools down, it soaks up all of the surrounding water like a sponge and forms gelatin. Gelatin is the cooked dietary source of collagen. [PDB-101, Molecule of the Month: Collagen] The digestive process must further process gelatin before absorption into the bloodstream.
   • The primary benefit of Bone Broth lies in its protein load. Every cup contains 6 to 12 grams of protein having 17 different amino acids. [Harvard Medical School, Harvard Health Publishing, 2015]
   • Common amino acids in gelatin are glycine, proline, valine (this is an essential amino acid which means you need to eat it because the body can’t make it), lysine, alanine, and arginine. Some people take these as supplements, but they are also in the gel one gets making bone broth. Many of these amino acids (like glycine and proline) are needed to manufacture other important compounds in healthy bones, like collagen. [De Pietro, 2019 Medical News Today] [Karim et al 2009] [Easttoe 1995]
   • The Bone Broth Recipe matters! Its cooking process converts the collagen contained in animal skin, bone, ligament, and tendons (or fish skin, bone, and fins) into gelatin. Amino acids contained in bone broth vary according to the preparation used. Longer cook times and use of more collagen rich bones resulted in higher amino acid levels. [Alcock et al 2019] But if there’s histamine concerns, reduce the cooking time to 2 to 4 hours to reduce histamine levels. Rarely, you may not tolerate Bone Broth. To learn more about histamine, begin reading [Sánchez Pérez et al 2018].
   • Nutrient-wise, Bone Broth contains some water soluble vitamins (like vitamin C, B1, and folate) and minerals (mostly potassium) that comes from the vegetables added to make Bone Broth, but not the bones! Bone Broth itself is NOT calcium-rich and that’s important because so many bloggers get it wrong and say that Bone Broth is calcium-rich. It is later, when Bone Broth is used to make soups and stews that nutrient vitamin and mineral levels dramatically increase due to the vegetables that are added in the recipe. [Queensland Government, Queensland Health], [LaMotte CNN 2016]. [Van Vynckt; SFGate, December 09, 2018], [Kimura et al 1990]. For those insights and more, please consider purchasing our Bone Broth Workshop book provided to participants in the Bone Broth Workshop. This book dives deep into all that can only be summarized here.
   • For many of us, ingesting collagen is rare in our modern diet- however when our ancestors ingested collagen they likely did so eating nose-to-tail, meaning they ate meat and organs from the whole animal, which are complete proteins, in addition to gelatinous matter.
   • That Bone Broth can be easily made for pennies is important because the few commercial traditionally made Bone Broths are pricey (accessed Aug 2020): US Wellness Meats: Bone Broth is $34.95 for 16 oz., stock is $26.35 for 38 oz.  Pete’s PALEO Bone Broth: costing $68.98 for 96 oz,  Kettle and Fire’s Bone Broth: Broth: $7.99 for 16.9 oz. BTW, this is the only option having a nutrient label (12 mg of calcium, 10 g protein, 4 g collagen). US Wellness Meats told me theirs is coming soon!
4. SUPPLEMENT COLLAGE HYDROLYSATE, the MORE EASILY ABSORBED FORM of collagen. The body can’t absorb collagen in whole form. To increase collagen’s bioavailability, collagen supplements typically are hydrolyzed. This means that the bonds between collagen’s long amino acid chains are broken down (though the amino acids themselves are kept intact) via a chemical or enzymatic process. Peptides consisting of just two or three amino acids remain together. These broken down peptides are then faster and more easily absorbed into the bloodstream when they reach the small intestine. They are then distributed to different tissues in the human body. [Santa Cruz 2019] Both gelatin and collagen hydrolysate contain the same proteins (glycine, proline, and hydroxyproline). Collagen hydrolysate is the MORE EASILY ABSORBED FORM. [Sibilla et al 2015] 
5. MOST are surprised to learn that you need to eat A LOT of food to get 10 gms worth of gelatin or collagen hydrolysate:
   1. This chart shows food equivalents, amino acid wise, of milk, potatoes, meat, and bread that would need to be eaten for 10 gm of gelatin or collagen hydrolysate. This is the amount used in many studies that found benefit!  For glycine, you’d need to ingest 3/4 gallon of milk or 4 lbs of potatoes!  For proline, that is 2.7 lbs of potatoes, ~1/4 lb of meat, or ~6 slices of bread!  [CHCompendium]
   2. “This comparison confirms that collagen hydrolysate provides the required amounts of the most important amino acids for the cartilage metabolism much more effectively and more selectively than any other protein containing  food.“  [CHCompendium] You may also be able to access this report at https://lknlife.es/assets/files/Collagen%20report.pdf

Source [CHCompendium] pg47.

You may also be able to access this report at https://lknlife.es/assets/files/Collagen%20report.pdf

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How we use Great Lakes Collagen Hydrolysate

We’re so impressed with the science and benefits of collagen and collagen hydrolysate that we take collagen daily in the more absorbable form of collagen hydrolysate. We have always only used the product Great Lakes Collagen Hydrolysate (a collagen wellness leader since 1922). We can’t comment on other brands because we have not tried others since this works so great and meets our demanding quality requirements for purity. Anecdotally, many immediately SEE CHANGES to nails (stronger, whiter, harder), hair (fuller, shinier, and more body), and skin (plumper, firmer, and wrinkles disappear). For joint relief, as discussed below, it takes about 3 months of use to notice significant benefits.

How much to use? Do as the manufacturer says. For Great Lakes Collagen Hydrolysate (this Hydrolyzed Bovine Collagen Peptides is Type 1 and Type 3 collagen), just 2 Tablespoons provides 12 gms of collagen, and all you do is stir that into food!

Most add it to soups, hot or cold drinks, orange juice, oatmeal, smoothies, and pureed foods. It is nearly tasteless, odorless, and colorless, and it is easily digested.

The joint relief which led many to try the Great Lakes Collagen Hydrolysate, takes some patience with many seeing benefit at or before 3 months of using the Great Lakes recommended full dosing of 2 Tbsp, taken TWICE a day. 

• What we hear time and again is that stiff, painful, frozen joint symptoms gradually disappear. By the 3 month timeframe you realize benefit. Things you did that caused pain and symptoms, DON’T anymore. This timeframe happens to be consistent with the PubMed findings.
• Once you realize benefit, many find that the Great Lakes Collagen Hydrolysate consumed can OFTEN be cut in half (i.e., reduced to 2 Tbsp [12 grams], once a day) to maintain benefit.  Many of the above studies used a 10 gm dose. Some even find that dosing can be reduced from daily to 3 or 4 times a week for maintenance. 
• Guys, while we are not aware of any study finding concern with using collagen hydrolysate as noted above and on the packaging instructions, always check with your health professional before use for your unique circumstances and how you should use collagen hydrolysate.

Recently, we were approved and decided to become an affiliate for Great Lakes Wellness.

• Guys, we agreed to be an affiliate for them only because of the quality and health value of this product.
• To help with product comparison, Great Lakes Collagen Hydrolysate is an easily absorbed, additive and preservative free, grassfed replacement for whey and casein protein. It is Gluten-Free, iGen non-GMO tested, Keto Certified, PALEO Friendly, glyphosate-free, Kosher, Halal, All Natural, contains no MSG, and it’s FDA registered and GMP certified.
• It meets requirements for use on SCD and UMass IBD-AID diets. If you need more details, please visit the FAQ section of their website or direct message us here!!
• Whether or not you decide to buy something is completely up to you in concert with your medical providers. Mostly what we want is for you to learn the importance of collagen and collagen hydrolysate and decide along with your health care provider, if supplementing makes sense for you. If so, we mainly care that you do your research and use a quality product.

If you use our Great Lakes Collagen Hydrolysate affiliate link for purchase, your cost will be the same as had you gone direct (which BTW is the cheapest price we’ve ever found). At no additional cost to you, we may receive a small commission which helps to fund this website and keep its information current. Thank you from the bottom of our hearts.

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• Storage: Great Lakes Gelatin recommends that you store dry and NOT refrigerate.
• COST:To reduce cost, buy it in bulk! We buy the 8 lb. bag of Great Lakes Collagen Hydrolysate. If you aren’t ready to jump in with that size, there are smaller size options. So while one 8 lb. bag seems pricey at $136.99 (accessed Jan 8, 2020), it contains ~302 servings (each serving is 2 rounded tablespoons which provides 12 gm of collagen hydrolysate). This is the amount mentioned above for maintenance, and at that rate, it costs 45 cents per serving. It will take you 302 days to use up an 8 lb. bag, and that is 10 months time!
  1. If you use it twice a day as at the start, that’s only 90 cents each day, and it will take you 5 months to use up an 8 lb. bag! Do you see how reasonably priced this product is? We have told others, “If you don’t feel benefit, we’ll buy it back from you!” No one has ever taken us up on that offer! This product is that good!
  2. You can purchase smaller quantities. The single 16 oz. container costs $24.99, but it will only give 38 – serving (each serving is 2 rounded tablespoons), which equates to 66 cents each serving.

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One last important note –> Consider BOTH gelatin and collagen as supplemental protein with health benefits. The protein from them should NOT be counted into your total protein intake. This is because they lack one of the 9 essential amino acids.

• The human body uses 20 amino acids in various combinations to form the proteins our cells need to function.
• The body itself can create 11 of the 20. The other 9 – called essential amino acids – are amino acids that the body cannot make on its own; they must come from our diet. Some say there’s 8 essential amino acids because they omit histidine, but that is heavily debated. [Oliveira 2019]
• Because gelatin and collagen lack one essential amino acid, tryptophan, they aren’t considered a complete protein. For this reason, don’t count them into your total protein intake.
• Make certain to consume sufficient complete protein sources like meat, poultry, seafood, eggs, whey (dairy), or plant proteins.
• I have been told often that ingesting an animal protein along with the collagen would be synergistic and make the amino acids whole. So I always do that, usually eating a few spoons of yogurt along with my collagen supplement.

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Conclusion: Make Bone Broth AND consider supplementing Collagen Hydrolysate

This post is short so you can jump into making flavorful nutrient and gelatin-rich Bone Broth. This post also ramps you up the gelatin, collagen, and collagen hydrolysate learning curve. To learn LOADS MORE than this post–> Consider purchasing our Bone Broth Workshop Book \O/

It is imperative that we maintain, support, and boost our collagen because, alarmingly, we lose our ability to produce collagen, 1.5% per year beginning at age 20. As well, autoimmune diseases, aging, and stress impairs collagen quality. [Sibilla et al 2015] [Obagi, Scientific American 2005]

Collagen is such a super important compound within us health benefit-wise, that we take it daily in its most absorbable form, collagen hydrolysate. Those benefits includes putting the brakes on and reversing joint degeneration, improving bone mineral density, muscle, melting wrinkles, aiding sleep and digestion, and much more.

We have always only used Great Lakes Wellness Collagen Hydrolysate for its source ingredient quality, amino acid profile, and toxin and heavy metal safety profile.

We are so happy with Great Lakes Collagen Hydrolysate that we are disclosing that we were approved, and agreed to be, an affiliate for them. What that means is if you go through our link to make a Great Lakes Wellness Collagen purchase it will be at the same cost as had you gone direct which BTW is the cheapest price we’ve ever found. Using our affiliate link also means that we may earn a small commission. Guys, we agreed to be an affiliate for them only because we use Great Lakes Collagen Hydrolysate daily because of the quality and health value of this product, and not because of the commission we receive from your purchase. The decision is yours, and whether or not you decide to buy something is completely up to you and your healthcare provider. But if you use our affiliate link, it helps to fund this website and to keep its information current. Thank you from the bottom of our hearts!

As always, direct message us here or comment below if you have any questions!! Let us know if you’ve made Bone Broth or used collagen hydrolysate!

Best in health through awareness,

References: Bone Broth Recipe and the Science on Collagen Hydrolysate Benefits

1. Cleveland Clinic Health Essentials, Bone Broth: How to Make It — and Why You Should, Feb 2020.
2. Dr. Mark Hyman Bone Broth Recipe “nutrient-dense… immune-supportive” https://health.clevelandclinic.org/recipe-bone-broth-veggies-herbs/
3. Functional medicine doctor, Dr. Kara Fitzgerald, looked into the lead issue in Bone Broths and hydrolyzed collagen and wrote this great post that lets you download for free, their findings. They literally tested the lead content of 3 beef bone broths as well as the Great Lakes Hydrolyzed Collagen (what I’m recommending in this post). They also looked at 36 other toxic and essential minerals and metals in their samples, from calcium to zinc and aluminum to uranium. [Sheppard Davenport, MS, CNS, LDN, Feb 2019, Dr. Kara Fitzgerald Functional Medicine] Bone Broth Report: Investigating for Lead and Toxic Minerals PLUS Nutritional Value, https://www.drkarafitzgerald.com/2019/02/06/bone-broth-report-investigating-for-lead-and-toxic-minerals-plus-nutritional-value/. The Organic Consumers Associations White Paper, “The True Content and Faces Behind America’s Best-Selling Collagen“, with the Heavy Metals chart on the last page, is at https://www.organicconsumers.org/sites/default/files/collagen_white_paper.pdf
4. 2020 Dec 1 Stage IV Cancer: Dr. Patrick Hanaway’s Personal Experience with Functional & Integrative Modalities, Dr. Kara Fitzgerald and Dr. Patrick Hanaway, https://www.drkarafitzgerald.com/2020/12/01/stage-iv-cancer-dr-patrick-hanaways-personal-experience-with-functional-integrative-modalities/?mc_cid=83baf4e919&mc_eid=08c9a12c56
5. If you want even more detail than what this post offers for Bone Broth, gelatin, collagen, and collagen hydrolysate nuances, consider purchasing our Bone Broth Workshop book provided to participants in the Bone Broth Workshop. This book dives deep, including tips like: what nutrients are in Bone Broth, which vegetables can be used to increase nutrients in both Bone Broth AND in recipes that use the broth, how to source “clean” bones, what cooking vessels help keep the lead out of bone broth, how much to drink, how to make it for pennies (important because the few commercially available decent options are north of $16 for the quantity you’ll make using this recipe), and how to practically integrate Bone Broth into your diet. The book also provides links to the science on collagen, and collagen hydrolysate benefit for joint and skin. Also included in the science discussion is how cutting edge lead researchers [Favazzo et al 2020] are beginning to investigate the possible gut microbiome connection between collagen ingestion and disease mitigation (the focus is osteoarthritis)! Our Bone Broth Workshop book is priced at $25.
6. The MORE EASILY ABSORBED FORM of collagen, with PUBMED studies supporting loads of health benefit, is called COLLAGEN HYDROLYSATE. The collagen component of Bone Broth is so important for joint, skin, digestion, blood sugar, bone strength, sleep, sarcopenia support that we take it daily in the form of Great Lakes Collagen Hydrolysate (a collagen wellness leader since 1922) and our affiliate link!
7. Our Instagram
8. Traditional slow cookers have linings that can leach lead, especially with acidic foods. Manufacturers use cagey words to skirt the lead issue, like “Hamilton Beach specifications… prohibits the product from containing any measurable amounts of lead,” accessed Jan 8, 2020.
9. NPR article “There’s no safe level of lead in your blood.”
10. [Sánchez-Pérez et al 2018] Biogenic Amines in Plant-Origin Foods: Are they Frequently Underestimated in Low-Histamine Diets? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306728/pdf/foods-07-00205.pdf
11. May 2020, Collagen Market revenue to hit $6 billion by 2026, Says Global Market Insights, Inc. Collagen Market value is set to achieve over 8% CAGR between 2020 and 2026, impelled by rising collagen demand in the healthcare and medical sector, https://www.globenewswire.com/news-release/2020/05/21/2036847/0/en/Collagen-Market-revenue-to-hit-6-billion-by-2026-Says-Global-Market-Insights-Inc.html
12. [Deane et al 2020] Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551889/
13. [Warwick 2020] Which foods boost collagen production?]
14. [NIH Vitamin C Fact Sheet for Professionals]
15. [CHCompendium] Adam M, Clark K, Kasper H, et al. Collagen Hydrolysate and its Relationship to Joint Health: A Scientific Compendium. 1ed. Eberbach, Germany: GELITA Health Initiative; 2004. A 120 page document accessible at https://healthdocbox.com/Arthritis/67133092-Collagen-hydrolysate-and-its-relationship-to-joint-health-a-scientific-compendium.html and possibly at “Collagen Hydrolysate and its relation to joint health. A scientific compendium, 2004” You may also be able to access this report at https://lknlife.es/assets/files/Collagen%20report.pdf
16. [PDB-101, Molecule of the Month: Collagen]
17. [Santa Cruz 2019] Dietary Collagen — Should Consumers Believe the Hype? https://www.todaysdietitian.com/newarchives/0319p26.shtml
18. [Sibilla et al 2015]  An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies, https://benthamopen.com/ABSTRACT/TONUTRAJ-8-29
19. [Obagi, Scientific American 2005] Why does skin wrinkle with age? What is the best way to slow or prevent this process? https://www.scientificamerican.com/article/why-does-skin-wrinkle-wit/
20. [Jiang et al 2014] Collagen peptides improve knee osteoarthritis in elderly women, A 6-month randomized, double-blind, placebo-controlled study, https://www.researchgate.net/publication/285117930_Collagen_peptides_improve_knee_osteoarthritis_in_elderly_women_A_6-month_randomized_double-blind_placebo-controlled_study.
21. [Luo et al 2022] Efficacy and safety of Native Type II Collagen in Modulating Knee Osteoarthritis Symptoms: A Randomized, Double-blind Placebo Controlled Trial, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780623/
22. [Khatri et al 2021] The Effects of Collagen Peptide Supplementation on Body Composition, Collagen Synthesis, and Recovery from Joint Injury and Exercise – A Systemic Review, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521576/#!po=2.08333
23. [Wauquier et al 2019] Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627680/pdf/nutrients-11-01249.pdf
24. [Jendricke et al 2019] Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521629/ 
25. [Zdzieblik et al 2015] Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/
26. [Zdzieblik et al 2017] Effect of specific collagen peptides with various dosages on body composition in untrained men, https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/effect-of-specific-collagen-peptides-with-various-dosages-on-body-composition-in-untrained-men/CC4D2E336D179BD3D5F6A332778C0D19
27. [Favazzo et al 2020] The gut microbiome joint connection: implications in osteoarthritis,  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903327/
28. [Alcock et al 2019] Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803522/#SM1
29. [Harvard Medical School, Harvard Health Publishing, 2015]
30. [De Pietro, 2019 Medical News Today] Ten Benefits of Gelatin, https://www.medicalnewstoday.com/articles/319124.php
31. [Karim et al 2009] Fish gelatin: properties, challenges, and prospects as an alternative to mammalian gelatins.
32. [Easttoe 1995] The amino acid composition of mammalian collagen and gelatin
33. [Queensland Government, Queensland Health, Does how you cook veggies change how good they are for you?] https://www.health.qld.gov.au/news-events/news/how-to-cook-vegetables-nutritional-value, accessed January 9, 2020
34. [LaMotte CNN 2016] The healthiest ways to cook veggies and boost nutrition, https://www.cnn.com/2016/05/05/health/healthy-vegetable-cooking/index.html
35. [Van Vynckt; SFGate, Updated December 09, 2018] Cooking and Vitamin and Mineral Loss, https://healthyeating.sfgate.com/cooking-vitamin-mineral-loss-3853.html
36. [Kimura et al 1990] Cooking Losses of Minerals in Foods and Its Nutritional Significance, https://www.ncbi.nlm.nih.gov/pubmed/2081985, read full text at https://pdfs.semanticscholar.org/7f0a/9169808386f9f9c0c9349df6fd06451a7014.pdf?
37. US Wellness Meats: Bone Broth is $34.95 for 16 oz., stock is $26.35 for 38 oz
38. Pete’s PALEO Bone Broth: costing $68.98 for 96 oz
39. Kettle and Fire’s Bone Broth: Broth:$7.99 for 16.9 oz. BTW, this is the only option having a nutrient label (12 mg of calcium, 10 g protein, 4 g collagen). US Wellness Meats told me theirs is coming soon!
40.  Great Lakes recommended full dosing of 2 Tbsp, taken twice a day, and to store dry and not refrigerate.
41. [Oliveira 2019] The Essentials – Part One
42. [Kopple et al 1975 ] Evidence that histidine is an essential amino acid in normal and chronically uremic man, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC301830/

Update Oct 18, 2021: Great Lakes Wellness conversion link as well as their FAQ link modified due to the company name change <span class="updated">Last updated: January 19, 2024 at 13:08 pm</span> Activated New WP Last Modified Info Plugin.

Updated to 2023 conversion link.