SUMMARY: This post explains the disease epigenetics process because most think your genes are your destiny. That is actually not true. You are more than the genes you inherit from your parents! Genes predispose you to the disease (~66% of “you” is determined by your genetics), but the remaining 33% is influenced by epigenetic changes to the genes, and that is one mechanism through which disease is triggered, [Mellor, 2015 University of Oxford Podcasts]. That is why they study DNA identical twins having discordance for the same disease — they find epigenetic differences [Insights from Identical Twins] [NovaScienceNow, Epigenetics] While it is often unknown if epigenetic differences are a cause or a consequence of disease, many studies are providing evidence suggesting a potential role for epigenetic alterations in the pathophysiology (e.g. Type 2 Diabetes, asthma, brain disorders and neurodegeneration, Alzheimer’s, autism, Lupus, Chronic Fatigue Syndrome, colon and other cancers, Parkinson’s, ALS…). The bottom line: Even though you might be “predisposed” to disease (e.g. you have a genetic pre-disposition tendency to Alzheimer’s, anxiety, arthritis, autoimmune disorders, cardiovascular disease, depression, diabetes, hypertension, metabolic syndrome, obesity, and cancer — any disease with epigenetic involvement which seems to be all of them) you can STOP and REVERSE the epigenetic changes that trigger disease by modifying factors that affect epigenetics such as nutrition, stress, toxicity, exercise and drugs. [Mellor, 2015 University of Oxford Podcasts] [NIH, NICHD] [Moosav et al 2016] [Szarc vel Szic et al 2015] [Wopereis et al 2014] [Hartzell et al 2012] [University of Utah, Nutrition & Epigenetics] One whopping impact of these factors is to pierce the disease epigenetic process by altering the microbiome. The microbiome is what makes identical twins, not identical! And it’s the microbiome consequent metabolites (which is where over 70% of our immunity resides) that can change epigenetic mechanisms (like methylation and histone modification — NOTE: I won’t be “teaching” these mechanisms, I will however explain enough that you can EASILY understand the concept) which have onward effects including triggering or reversing disease in those predisposed. What this means is that you actually have a say in if you turn on or off genes with consequent trigger (or reversal) of disease. The recognition that environment, not genetics, is the primary driver of health and disease carries a strong message of personal empowerment and responsibility. Thus, included is a special section — EPIGENETIC EXPERT SUGGESTIONS FOR EATING FOR YOUR EPIGENOME! BAM — they sound a lot like those therapeutic diets I teach and blog about! Don’t be duped. A lot of disease is preventable — [WHO] says over 80% of all heart disease, stroke and type 2 diabetes AND over 40% of cancer! From the grim stats below, if you don’t already have disease you likely will and sooner than you expect! A balanced lifestyle that includes a healthy diet, exercise, & avoiding exposure to contaminants, may in the long run create a healthy epigenome. [TedED, What is Epgenetics? -Carlos Guerrero Bosagna.] Time to empower yourself to use epigenetics modifications to keep or move yourself off diseasespan!
SUMMARY: CME MICROBIOME Questions is where the rubber meets the road! I learn what you really take away from the evidence packed Introduction to Microbiome presentation!!! Not only was it a great turnout for the CME MICROBIOME, DISEASE, THERAPEUTICS, NUTRITION held OCT 25, 2017 in Pittsburgh, at Passavant Hospital (see this post for details), but the questions asked by these medical providers were spot on! Read below for some of the Q&A with focus on: What to do if on the “Avoid Diet”, the MIND Diet and Dementia Prevention, fermented foods, and the ketogenic diet — MACS, fruit and weight! The Therapeutic Manipulation of Microbiome slide (see below) shows how microbiome nourishingly sick the Standard America Diet is. Some call this diet void of MACs, or microbiota-accessible carbohydrates, leaving the microbiome to nosh on our carb-rich mucus gut lining, when dietary pickings get slim. [Desai et al 2016] This CME crowd took their first ever pass into the anaerobic world of this newly discovered organ and saw its systemic body-wide devastating health impact when the gut lining becomes compromised (see the below slide) ⇒ The next step is to learn my bolt on presentations of diet ⇔ lifestyle changes that can move this organ to health. ♥ If you are a business (especially self insured) looking to reduce healthcare costs, CONTACT me because microbiome information is what your employees NEED to hear to keep (or move) them off diseasespan — see my SERVICES! If you are an individual or other group wanting to hear this information, CONTACT me to make that happen!!!
SUMMARY: Friendly reminder to attend the CME Microbiome, Disease, Therapeutics, and Nutrition at UPMC Passavant Hospital, Pittsburgh, October 25, 2017, Assembly Hall, noon–1PM! See the last post here for specifics, but in general, THERE IS MORE TO THE STORY, and I will share those no-nonsense insights into microbiome associations for the hypertensive, atherosclerotic, obese, cognitive impairment, Alzheimer’s, and IBS conditions (and more) as well as therapeutic diets being used for those disease conditions. What to eat information has been muddied by industry production of ubiquitous processed foods marketed as healthy foods. This CME shares tools your patients can use now to turn around disease as well as recognize its role in increasing drug efficacy and prevention of medication failures. Public Microbiome Awareness Education gives the ‘why’ behind disease, and is patient Motivation for Action, not paralysis. This CME will help establish your patients healthy relationship with food and turn around their disease status. Listen too as local patients share how they use evidence–based microbiome therapeutics to induce and maintain remission for autoimmune disease, and learn about the Pittsburgh—based cohort forming for inclusion in upcoming leading light microbiome researcher, Dr. Rob Knight, UCSF studies looking at ferment consumer gut microbiomes.
SUMMARY: Microbiome CME!!! If you are a healthcare provider or medical professional, attend this CME Microbiome. Disease, Therapeutics, and Nutrition at UPMC Passavant Hospital, Pittsburgh, October 25, 2017, Assembly Hall, noon–1PM! The new discovery of the microbiome, a 2 to 3 pound organ having a key role in over 70 percent of our immunity, is a paradigm shift changing up our understanding of physiological and psychological health and disease. This CME shares current no–nonsense evidence of what the microbiome is and includes valuable insights into what is overselling the microbiome. Click here for the PDF: CME Microbiome. Disease, Therapeutics, and Nutrition, Oct 25, 2017, UPMC Passavant Hospital. LEARN eye-opening insights and actionable tips about the KEY role the microbiome plays in your organ of choice, in chronic disease (2/3 of deaths in Allegheny County are attributed to chronic disease) including hypertension, heart disease (this leading cause of death, at 30% in Allegheny County, is higher compared to the state of PA), diabetes, metabolic syndrome, obesity, cognition, Alzheimer’s, IBD, IBS, MS, and more, as well as its role in increasing drug efficacy and prevention of medication failures. Listen as local patients share how they use evidence–based microbiome therapeutics to induce and maintain remission for autoimmune disease, and learn about the Pittsburgh—based cohort forming for inclusion in upcoming leading light microbiome researcher, Dr. Rob Knight, UCSF studies looking at ferment consumer gut microbiomes (see bio below). Bottom line — DON’T MISS THIS CME — Healthcare provider, medical professional, AND patient education/awareness of this organ is the “why” that causes patient diet and lifestyle behavior changes that moves them OFF diseasespan. The only way to do better is to know better. —poet Maya Angelou. The point of CME is to try to move the field and do right by our patients. Attend and LEARN the role of this new player in the organ/disease of your choice!
Summary: I’m giving you a heads up on a book I read by Dr. Dale Bredesen titled, The End of Alzheimer’s. I think everyone needs to read this book for proactive and reactive neurologic health ranging from mild cognitive impairment, to dementia to Alzheimer’s. Alarming statistics: 15% of the population will succumb to Alzheimer’s. 65% of Alzheimer’s patients are female. If you are female, your chance of getting Alzheimer’s is greater than getting breast cancer. Dr. Mark Hyman’s email dated Sept 5, 2017 stated: “10 percent of 65-year-olds, 25 percent of 75-year-olds, and 50 percent of 85-year-olds will develop dementia or Alzheimer’s disease.” Do your brain a favor, read The End of Alzheimer’s to understand Alzheimer’s Dementia Bredesen Approach. In fact, use the Institute for Functional Medicine link, Facebook Live with Dale Bredesen, MD – September 10, 2017 at 7 pm CDT to download your free chapter. I did! I read tons of full-text studies covering microbiome, health, disease, therapeutics, and nutrition, most behind paywalls. Paywalls are one reason there are many health/wellness books written by the ‘experts’. I have bought a few of those, and I use them over and over again for reference. The End of Alzheimer’s is one such book I am certain. Put it in your tool aresenal too, for your brains sake.
SUMMARY: No doubt you’ve heard and read the USAToday.com article, Coconut oil isn’t healthy. It’s never been healthy, June 16, 2017 where the American Heart Association said in a new report, “We advise against the use of coconut oil.“ Given that the amour de ma viemy sent me that article, I wanted to document the issues and truth of the matter! Learn in this post, Coconut Oil Safety, Issues, and Truths of the Matter because getting fats right impacts breast cancer, diabetes, metabolic syndrome, and cardiovascular diseases just to name a few! The Pearl: Eat coconut oil, not 24/7, but that is just the same as with any other food. I mean, brains and trees (cauliflower and brocoli) are good for you, but you wouldn’t eat those 24/7! Use coconut oil for hot uses and to add some fat (which your body and brain truly needs) into your diet. But mix up those fats choosing among the healthy fats: EVOO (unadulterated), avocados, butter, handful of nuts, whole fat dairy in whatever form tolerated (see here for lactose-free SCD yogurt and lactose-free SCD cheeses), and yes, coconut oil (unrefined and cold pressed)!
SUMMARY: Bottom Line of this post: You want OFF the IBS diseasepan! WHY? Because — putting aside pain, bowel issues, and bloat — IBS can alter the brain size and function in the emotion and sensory processing areas when having it a long time along with early life stressors [Labus et al., 2017], it is associated with a lot of diseases, and there are a lot of surgeries performed inappropriately because of misdiagnosis or poor manangement of IBS! DISEASES associated with IBS — it is not comprehensive: Type 2 Diabetes, metabolic syndrome, fibromyalgia, chronic fatigue syndrome, IBD, CFS/ME, autism, anxiety, depression, MS, and Parkinson’s. Inappropriate SURGERIES occurring due to IBS misdiagnosis — appendectomy, cholecystectomy, ovarian, and hysterectomy. See below for All of those links. There are lots of ways to get off the IBS diseasespan! Learn in this post that it is YOUR choice: IBS, Microbiome, Fodmaps, Probiotics, Mindfulness-based stress reduction, Cognitive behavioral therapy works… or targeted drugs! Or not drugs — the efficacy of that current US standard of care: “The physician should also emphasize the chronic nature of this syndrome [IBS] because nearly 75% of patients continue to have a diagnosis of IBS 5 years later.13 ” [Occhipinti et al., 2012]. “Many different drugs have been suggested for IBS treatment, but their real benefits are very debatable.” [Bellini et al., 2014]. Don’t be surprised. In 2012, the FDA changed the endpoints of those drug studies to stop being only one endpoint because of how multi factorial IBS symptomolgy is, and the Bristol Stool Chart — defining what is a ‘normal BM’ (which you’ll learn in this post) — despite being around since 1997, is only now being validated, 2016! Contrast all this to the UK British Dietetic Association guidelines for IBS — low FODMAP diet is the second-line intervention [Catassi et al., 2017] [McKenzie et al, 2016] [UK evidence-based practice guidelines for dietetic management of IBS in adults 2012 PDF]) as it helps about seventy-six percent of IBS patients [Magge et al., 2012] [Bohn et al., 2015] [Staudacher et al., 2011] and yet, it has come under attack with the current US standard of care still NOT recognizing the FODMAP diet (see this post). A rebuttal to all the rift recently published in 2017, authored by Monash University ressearchers, the creators of the FODMAP diet. See [Hill et al., 2017] To piggyback the diet fix, studies continue to find that probiotics might be something to think about for some cases of IBS — see [Whiteley, 2016]. Wondering about IBS and what early life stressors might mean? That group had more history of early life trauma (general trauma (31 items), physical (9 items), emotional (7 items), and sexual abuse (15 items)) AND they had longer duration of IBS symptoms. [Labus et al., 2017] While we can’t change our early life stressors, there are lots of ways to tackle IBS using diet, probiotics, mindfulness-based stress reduction, cognitive behavioral therapy and targeted drugs — according to the Monash rebuttal [Labus et al., 2017]. Now you know! Protect brain size and function, avoid potentially needless surgery and improve your disease status by fixing IBS; LISTEN to your gut! Unbelievable… check out the global prevalence of IBS:
SUMMARY: I always share good worthwhile Workshops. Here’s your chance to participate in a FREE Workshop led by Dr. Mark Hyman’s group. He calls it a Detox Workshop, but it actually is going to get you off the sugar and carb addiction roller coaster. This Dr. Hyman Free 10 Day Detox Challenge is something everyone should try! What you learn will change your health and help to keep you off, or move you off, the diseasespan! Dr. Hyman is the Director the Cleveland Clinic Center for Functional Medicine which opened in 2014. Since then, it has expanded twice to accommodate more patients, and the wait list at the start of 2017 was still 3,000 patients. Good luck getting seen there! Dr. Hyman is also the founder and medical director of The UltraWellness Center, chairman of the board of the Institute for Functional Medicine, a medical editor of The Huffington Post, and was a regular medical contributor on many television shows including CBS This Morning, Today Show, Good Morning America, CNN, and The View, Katie and The Dr. Oz Show. Participating in one of his Workshops… WELL… It doesn’t get much better than that! Sign up. NOW!!!
Summary: These Coconut Flour Salmon Cakes Gluten free SCD PALEO are a game changer! These gems are way better then traditional restaurant versions AND they eliminate all those filler ingredients like breadcrumbs, mayonnaise, and Worcestershire; see below for why I never use those ingredients! When you open my fridge you’ll often find these salmon cakes for quick grab, but they are totally EASY, eloquent, and redic delic as an appetizer or entree for guests and at holiday celebrations. This recipe uses coconut flour and eggs as binder, and they hold their shape beautifully! They are PALEO, SCD, GAPs, and UMass IBD-AID legal. They are FODMAP and AIP legal with the garlic and onion HACK and other modifications detailed below. Truth be told, we often snack these at the end of the night, with a glass of red wine (a great anti-inflammatory — see here), candle light, and a drizzle of real fermented SCD Dijon Mustard — recipe is on my Pinterest Condiment Board. This is the lifestyle pillar I talk about so often! Hitting your body with safety signals from as many different directions as possible truly FEELS and tastes great!
SUMMARY: I want to let you know about this amazing 3rd annual Citizens of the World Wellness Conference, that you can attend, hosted by The Sisters of Charity of Seton Hill on May 5, 2017, in Greensburg, PA. This year, “Lifespan Rhythms: A Focus on Memory, Hormones, and Vitality” is the theme. Come and learn the latest studies about the Vitality, Memory, Hormones link. Expert speakers throughout the day will discuss how to support families across the lifespan with a focus on MEMORY IMPAIRMENT. I participated in last years conference and am thrilled to do so again this year. I don’t normally give you a heads up of opportunities like this unless they are truely worthwhile learning opportunities. This conference makes my cut! If you can attend, you’ll leave with a boatleg of practical information! Come learn about the Vitality, Memory, Hormones link.