Tag Archives: biome

Breast microbiome and Cancer Risk Assessment tool

SUMMARY:  Recent studies challenge dogma and find that healthy breast tissue is NOT sterilafter-all. The breast seems to have its own microbiome of bacteria and such seems protective; dysbiosis (REDUCED richness and/or certain species) was associated with breast cancer.   Furthermore, healthy breast tissue had bacteria  Sphingomonas yanoikuyae (Proteobacteria), which is better known to degrade pollutants in the environment. In the cancer samples, there was little to none of S. yanoikuyae; this bacteria is able to use estradiols including 17-β estradiol, which are believed to be associated with breast cancer. The authors could not determine causality due to lack of S. yanoikuyae. Learn in this post microbiome implications for breast cancer, free online breast cancer risk assessment tools, ongoing studies personalizing cancer risk for mammogram frequency to reduce false positives, and look over a decent listing for cutting your risk for breast cancer in the first place from Prevention. Included specifically on that list is carotenoid loads which I preach about, including the need to consume carotenoids with the correct healthy fat so as to absorb them. LOWFAT DOES NOT ABSORB THOSE CAROTENOIDS.

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Finally, an IBD microbiome drug goes to clinical trial

Summary:  Seres Therapeutics began its Phase 1b placebo controlled clinical trial on Dec 14, 2015, for SER-287, which is the first drug aimed at the microbiome for a non-infectious, chronic condition, ulcerative colitis (UC).  This is the first IBD microbiome drug that actually targets the constituents of the microbiome. This approach treats chronic disease without suppressing  the body’s immune response. Instead, specific strains of bacteria are introduced that re-balance the billions of different types of bacteria that are in the digestive tract, which then increases immunity and manages the disease.  Instead of being immunosuppressive, this treatment targets the root cause of UC  which is gut dysbiosis, increasing immunity. SER-287 clinical trial is currently recruiting participants if you are interested; contact information is below.

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Do microbiomes on drugs look healthy? Biologics & PPI

Summary:  I’ve wondered literally for years now, ever since I first learned of the microbiome, do microbiomes on drugs look healthy?  I call it the “drugged microbiome,” and I (foolishly perhaps) expect the drugged microbiome to look like a “healthy microbiome”  since this is where 80 to 85% of our immune status resides.  We already know that ~60 drugs are known to be affected by the microbiome  though researchers suspect the real number is much higher.  My question turns this on it’s head and asks, 

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SCD thoughts given DrOz 3 Day Cleanse, Microbiome

SUMMARY:  Finally! A peek into our trillions of innards on a 3 day fruit and vegetable blitz!  Spoiler alert:  There is NOT much impact 10 days after stopping that 3 day cleanse, microbiome resulting from healing diet tenets persist!  

And that, I think, is the lesson to be learned for the healing diets such as SCD, GAPS, PALEO, AIP, WAHLs, to name a few.  Realize, the tenets of these healing diets are for everyone if you want to prevent chronic disease, not just those with chronic disease.  These protocols increase vegetables and fruits beyond what the normal Standard American Diet (SAD) yokel is consuming and adds in healthy fats so fat soluble vitamins are actually absorbed.  This is done concomitant with ditching processed foods,  including processed sugars, and other inflammatory foods.  How powerful are these tenets?  They are healing and inducing remission in messed up impoverished gut microbiomes, and some of those folks are only 80% compliant with the diet!  Nuff said.  Shouldn’t you know what these tenets are?

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50 IBD SCD remission patients: RUSH paper

SUMMARY:  In August, 2015, RUSH University published  their study of 50 IBD Specific Carbohydrate Diet (SCD) remission patients: The Specific Carbohydrate Diet for Inflammatory Bowel Disease: A Case Series. This is the largest report on a series of patients with IBD following the SCD to date and describes their clinical characteristics.  50 patients in remission eating SCD case series are reported which comprise: 36 subjects had Crohn’s Disease, 9 subjects had Ulcerative Colitis, and 5 subjects had in-determinant IBD.  

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US Antibiotic Resistance and WHO

SUMMARY:  Antibiotic resistance is invisible to most of us until you, a family member, or an acquaintance acquires such an infection.  You can check out the slides below to see state by state, US Antibiotic Resistance Risk and state Antibiotic Use.  erhaps the most reasonable mechanism to prevent antibiotic need in the first place, is explained in the post PRESERVE & RESTORE LOSS OF MICROBIOME DIVERSITY IS AGGRESSIVE PREVENTATIVE MEDICINE.  These concepts are especially important given that the average American has lost 1/3 of their microbiome diversity, as estimated by Dr. Maria Gloria Dominguez-Bello as seen on this interview for the film “Microbirth.”   Another study estimates 1 in 4 have 40% less bacteria (see This Danish study, or read the scientific article here).  

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Preserve & Restore Loss of Microbiome Diversity is Aggressive Preventative Medicine

SUMMARY:  Aggressive Preventative Medicine means preserving the microbiome you have and restoring any loss incurred.  See how far that thought goes with your doctor!  Diet really does work to alter the microbiome and can help to restore loss of microbiome; for example, fermented kimchi actually positively impacted metabolic syndrome factors including systolic and diastolic blood pressures, percent body fat, fasting glucose, and total cholesterol.  

⇒⇒  This post teaches how to reduce the loss of microbiome diversity and restore such – crowding out concept.

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16S rRNA challenges healthy vaginal microbiome; ferments & coconut oil rock!

SUMMARY:   Incredulously, the latest 16S rRNA research now challenges what was thought for years to be a ‘protective,’ ‘normal,’ and healthy vaginal microbiome. Our many microbiomes ideally are “inherited” and originate from our passage through the vagina, and yet it seems a ‘healthy’ and ‘normal’ vaginal microbiome has been elusive; in fact, many women have a compromised vaginal microbiome and many are asymptomatic, or perhaps not… 

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We see & perceive things differently; Neither is superior to the other

SUMMARY:  The ‘blue/black white/gold dress‘ incident is a really good way of acknowledging that people see and perceive things differently and one way is not necessarily superior to the other.  I see and appreciate this in every diet conversation I have.  I focus a lot on diet; but lifestyle tweaks help many achieve wellness when clean diet isn’t enough.  Initial microbiome studies show that stress can result in changes to the gut microbial community, specifically bacteria in the genus Lactobacillus are consistently reduced.  If clean diet isn’t enough, move onto stress busters that data shows literally reduce inflammatory markers — affirmations and meditation do such.

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Nice, SCD increased F. prausnitzii… hugh?!?

SUMMARY:  This post is a followup to the post, IBD CROHN’S: SCD INCREASED MICROBIOME DIVERSITY BUT LOW RESIDUAL DIET REDUCED DIVERSITY.   It discusses the significance of the finding that SCD increased F. prausnitzii within the microbiome for Crohn’s patients eating SCD.  I’d suspect however, that similar results occur even for non-Crohn’s SCD consumers,which would be a good thing.  For details of the microbiome changes due to SCD, such as the microbial diversity increased to include 134 bacteria belonging to 32 different classes (Figure 8), the bacterial families over represented in the increase in SCD included over 20 species of the non-pathogenic clostridia family…  read the post  IBD CROHN’S: SCD INCREASED MICROBIOME DIVERSITY BUT LOW RESIDUAL DIET REDUCED DIVERSITY.

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