SUMMARY: I’m sharing two weeks of FREE access to the Town Hall Medicine Microbiome Talks from twenty-one key microbiome researchers and includes clinicians integrating microbiome into therapeutics! This educational series is presented by University of Toronto’s Heather Boon PhD, Dean of Leslie Dan Faculty of Pharmacy and Stewart Brown, Founder & CEO, Genuine Health, a science based natural health company. These talks are short and to the point, AND you can download the transcripts for later reading. There has been a ton going on in the ivory towers of academia and science research uncovering just how important the gut microbiome is to health and wellbeing and its impact on the immune system. Microbiome associations are now known for hypertension (34 percent population prevalence ), atherosclerosis (39 percent), anxiety and depression (10 percent), weight gain, obesity (29+ percent), autoimmune diseases (20 percent — mostly women), Type 1 and 2 Diabetes (36 percent), metabolic syndrome (34 percent), IBD (10 to 15 percent), asthma allergy, autism, schizophrenia, Alzheimer’s, Parkinson’s, stress-induced and progressive neuropsychiatric diseases, AND prolonged low-grade inflammation which is behind most all disease (51% of adults have at least one chronic disease, 27% of kids have one or more chronic diseases). Yet none of microbiome — disease impact is pouring down to us mere mortals none the less doctors — I would know; I teach Microbiome CME. When twins having 100% identical human DNA only have 40 percent of the same gut microbiota, imagine how different your microbiota is from everyone else. Spoiler alert: Your gut microbiota is 99 percent different from everyone else and our microbiota explains why each and every one of our bodies (and minds) behave so differently! Knowledge is power, and these talks share how microbiome understanding is being put on the forefront of therapeutic integration to reverse and prevent disease. Now that is aggressive preventative medicine especially since 70 to 80 percent of our immune cells reside in the health of our gut microbiome. Enjoy the listen, and Merry Christmas, Happy Holidays, early!
SUMMARY: Here is the Concise Summary of Specific Carbohydrate Diet, or SCD Studies with a focus on SCD for dietary treatment for Inflammatory Bowel Disease (IBD). Actually though, SCD is used for many conditions, not just IBD. This post focuses on the boatload of studies evaluating SCD for IBD because that is where most of the SCD research is happening. The findings support that once gut irritating foods are removed, the immune system changes because the gut microbiome changes. That should be true for whatever condition SCD is used for. Take this Round-table of SCD studies to your doctor and ask for support especially if for IBD. They should liaison with those already integrating the SCD into IBD dietary therapeutics. SCD helps IBD with or without medications and can be used to induce remission for many with and without medications. Always, the goal of treatment is IBD remission, not necessarily medication-free. Half of the 417 patients surveyed [Suskind et al., 2016] use the SCD to induce remission; the other half use it adjunct to medications because of medication failure. Think how many guts could be saved! Dr. David Suskind (leading light GI at Seattle Children’s Hospital integrating SCD into IBD clinical dietary therapeutics) explains [Suskind Dietary Treatment YouTube, 2016] that some use SCD alone if with mild to moderate symptoms at diagnosis. Others use SCD along with medications and then once in remission, it may be possible to wean off medications. Consider giving some of the SCD tenets (especially the emulsifier elimination) a try regardless of your disease, or for aggressive preventative health. Diet that removes gut irritants is that powerful because it changes up the microbiome where over 70% of immunity resides! What do you have to lose????
Summary: The 2014 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism brought out anecdotal parent findings that autism symptoms improved or worsened on antibiotics. Baylor College of Medicine study in conjunction with Texas Children’s Hospital, is now investigating those findings! If you have an autistic child, consider enrolling now before they are sick, so you have a test kit if prescribed an antibiotic over the next two years. You would send microbiome samples pre and post the antibiotic. Those are to be evaluated for changes to behavior and the microbiome — the bacteria, yeasts and fungi that also inhabit the gut, as well as examining metabolites (small chemical molecules) found in the GI tract. The study is free to participants and fully paid for by N of One: Autism Research Foundation which is founded by John Rodakis, the father of an autistic son who experienced symptom improvement due to an antibiotic dose Thanksgiving 2012. Participate if you can to increase understanding of Antibiotics, Autism Symptoms which at present, has a gap in the published autism research. This initial data may more effectively sub-type autism and develop and deliver more effective microbial-based interventions.
SUMMARY: Why Must You Understand Epigenetics? Because epigenetics is the real driver of your health status, and diet plays a major role in gene expression (aka epigenetics), at least in this post’s animal study! Mention this fun fact at holiday gatherings as others notice and comment — good and bad — about your favor of healthy whole foods with resist of the nutritionally empty and microbiome harming options! Epigenetics is a big word but it simply means the process by which your genes are turned on or off (aka expressed) in good or bad ways. You already know, diet pre-selects “who” comprises the gut microbiome. This post shares the University of Wisconsin-Madison mouse study which found that the molecules produced by the microbiome (aka metabolites) tells our genes what to do (turn on or off). This study looked at two diets: a carbohydrate rich diet (one rich in plant carbohydrates similar to fruits and vegetables humans consume) and pitted it against the Western, Standard American Diet (SAD) (think high in simple refined carbs, added sugars, and unhealthy fats — this is found in most all home cooked, grocery prepared, and restaurant meals as they use convenient processed ingredients). Their results showed the plant based diet yielded a more rich microbiome which in turn, produced metabolites that seemed to favor host-microbe communication as they chemically communicated with cells, including cells FAR beyond the colon (the liver and white fat tissue), to dictate gene expression and health (metabolic — insulin, lipid to name a few) in its host. In contrast, the metabolites of the SAD did not provide this communication likely because it was MISSING the necessary metabolites to do so! If you think this is awkward party talk, what is even MORE AWKWARD is feeling others watch what you eat so that they can learn what foods express their genes best! You’ve worked hard to learn microbiome. I am in awe and proud of you. Now it’s your turn to pay it forward and teach others by doing!
SUMMARY: Yesterday, Dec. 1, 2016, a major gut — brain animal study paper published finding for Microbiome: Parkinson’s begins in gut, at least in mice. While this has been kicked around for years, this animal mouse study finally proves the theory, and this post documents the Dec 2016 Parkinson’s mouse study. You’ll recognize some of the authors: Rob Knight, Sarkis K. Mazmanian, Ali Keshavarzian, and Kathleen M. Shannon if you follow my work as I have worked with these labs or follow them closely. If you have or are concerned with brain and cognition, be it autism, MS, cognitive decline, Alzheimer’s, Parkinson’s, etc… consider extending this papers findings and seriously start looking in your gut for answers to the why in your brain. I can’t stand that it takes so long for folks to get real and realize that what goes into our body impacts the brain too. Usually they don’t get it until they have major symptoms of impairment. It’s also beyond me that folks don’t understand that bowel habits are windows into how our body handles what we put into it. My pearl there is that you need to know what the Bristol Stool Chart is and how to use its incredibly useful information to learn what your body, especially what your microbiome or those trillions of beasties, thinks about the menu you feed it. Though the human studies are far off, the writing is on the wall. if you care about your brain, START fixing your gut. This post was updated Jan 25 and 26, 2017 to include a webinar and podcast dated Jan 17 and 19, 2017, discussing the Mazmanium study along with insights for diet and the Parkinson’s microbiome.
SUMMARY: Our food choices are fundamental for health. The next Integrated Functional Medicine Grand Rounds installment with Cleveland Clinic is coming up on Tuesday, December 13, 2016. Listen, for FREE as Dr. Alessio FASANO, MD speaks on How Early Nutrition Influences Microbiome, Disease. This is an incredible opportunity officially titled: “How Early Nutrition Influences Gut Microbiome and Metabolic Profiles in Health and Disease: Shifting From a Disease-Centered Approach to Patient-Oriented Functional Medicine.” For background, I have followed Dr. Fasano’s work for ages. He is a leading gut inflammation light who put Celiac Disease, and Non Celiac Gluten Sensitivity, on the map in the US when all US health agencies literally told him those were “across the pond”. When that happens, you know you are about to make a major break thru that will ruffle lots of feathers. He persevered, and his findings will re-write the medical books. Those findings opened the doors for what is now understood as: Gut permeability ⇒ immune stimulation ⇒ inflammation ⇒ gut and systemic ramifications ⇒ autoimmune and chronic disease. Listen in to Dr. Fasano, FREE, Early Nutrition Influences Microbiome, Disease!
SUMMARY: This is not a 1950s sci-fi movie. This is what is likely happening now in your gut according to an amazing study just now publishing in Cell. If you are eating the Standard American Diet, the normal, helpful bacteria in your gut are not getting natural whole food fiber. Instead they are being fed fiber additives supplemented in processed foods, or isolated fiber supplements you are buying. Surprisingly, both the fiber additives and the supplements FAIL to feed your microbiome, and instead, they CANNIBALIZE the mucus lining for fuel, at least for mice, according to this study. Repeat: Fiber Additives Starve Gut Microbes. They Eat Mucus Lining. That compromises the intestinal barrier role in preventing pathogen infection. Bottom line: EAT WHOLE FOOD BASED FIBER to feed your microbiome, AND DON’T COUNT ON THE FIBER ADDED IN PROCESSED FOODS OR THE SUPPLEMENTS YOU TAKE FOR THAT FIBER. No wonder so many are sick.
SUMMARY. This post looks at other ways beyond Celiac and NCGS, that wheat can affect EVERYONE and includes new groundbreaking research being presented in Vienna. The bottom line: Move over gluten, ATI wrecks guts too, and… we have a new picture of what the inflamed gut looks like! ATIs, or amylase-trypsin inhibitors, are non-gluten proteins in wheat. ATIs activate specific types of immune cells [toll-like receptor 4] in the gut and other tissues. ATIs can trigger gut immune reactions that can spread to other tissues in the body. How bad can this get? “ATIs can lead to the development of inflammation in tissues beyond the gut, including the lymph nodes, kidneys, spleen and brain. ATIs can worsen the symptoms of pre-existing inflammatory based conditions like RA, MS, asthma, lupus, IBD, and non-alcoholic fatty liver disease…” The final big hit: “ATIs may contribute to the development of non-coeliac gluten sensitivity (NCGS).” No wonder so many feel better ditching wheat since you knock out both gluten and ATIs AND decrease inflammation not just in the gut, but systemically! For an example, IBD and neurological association to ATI is discussed below! What about the non-gluten containing staples you may be consuming? Those displayed no or little of the toll like receptor 4 stimulating activity whereas ATIs displayed much!
SUMMARY: Plenty of studies find anti-inflammatory effects of dietary antioxidants such as green tea for chronic disease. Even in IBD patients, who have a very messed up microbiome (a finding of the American Gut data), the benefits of antioxidant therapy is well documented (see below studies). Read here about a simple EASY N=1 hack for one IBD patient that shut down a mild psoriasis skin flare that began two years ago. They flared psoriasis, but not the autoimmune IBD, eating strict healing diet Specific Carbohydrate Diet (SCD) probably due to a gluten/sugar airborne exposure. The hack that worked for stopping psoriasis: Green Tea, Black Tea with Lemon Juice antioxidant blend! I share their recipe here! It is simple enough that you may want to add it to your immune calming anti-inflammatory arsenal too! Make sure to see below for why it is important to NOT drink Green Tea for antioxidant benefit along with Iron.
Summary: Say you use to have Type 2 Diabetes. How? READ this study from ITALY. Ma-Pi 2 diet for Type 2 Diabetes WORKED. Type 2 Diabetes, diet, microbiome; the Ma-Pi 2 diet for Type 2 Diabetes is dietary modulation of microbiome. Although this diet BEAT the current recommended diet by Italian professional societies (CTR) consider using it short term and supplementing the diet similar to recommendations by Drs. Mark Hyman and David Ludwig noted below, with healthy fat, wild caught fish, berries, and fermented dairy (if tolerated), since the restriction of certain groups could lead to nutritional deficiencies especially vitamin B12 and calcium. Actually, Dr. Hyman just offered his 10 Day Detox diet for FREE to the public that clarifies all the food recommended. You can read about that at the post, JOIN DR. MARK HYMAN FREE 10 DAY DETOX CHALLENGE. You may still be able to take advantage of this opportunity. To clarify the carb loads for diabetes, Dr. Ruby Aujla’s Advice to Diabetes page (which is 100% in accord with Dr. Hyman’s 10 Day Detox) says, “Get your carbs from colorful plant based sources. Even breakfast should be brimming with those! Bread, White Rice, Pastas, White potato, Cereals (even cereals marketed as ‘wholegrain’), Instant Oats, Refined Grains, white potato are OUT.” The Ma-Pi2 study describes in pain staking detail, microbiome wise, microbiome impact. Talk with your doctor for Ma-Pi 2 integration with therapy. Managing the microbiome through diet is new, grassroots, and it works. SAVE a friend and SHARE this post.