Blog: Autism, Blog: Microbiome

Crowd Sourcing DNA Sequencing for Autism

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“Lots of things are mysteries. But that doesn’t mean there isn’t an answer to them. It’s just that scientists haven’t found the answer yet.”   – Christopher John Francis Boone, “If you put 10,000 people’s genomes in the cloud, could you demystify autism?”

It’s happening!   Cancer and autism is leading the way… “Medicine will soon rely on a kind of global Internet-of-DNA which doctors will be able to search on Goggle’s cloud platform. “Our bird’s eye view is that if I were to get lung cancer in the future, doctors are going to sequence my genome and my tumor’s genome, and then query them against a database of 50 million other genomes. The result will be ‘Hey, here’s the drug that will work best for you.’ ”“

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Pillar: Toxins, Recipes: Fish, Recipes: Poultry, Recipes: Vegetables, Whole Food

Vegetable Spiralizer Noodles. No gluten & arsenic grains!

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Many need a spaghetti substitute especially when first decreasing gluten and grain consumption, and instead are increasing vegetable consumption.  A Paderno Spiralizer (this Williams-Sonoma website has a nice How-To use video) is what I use to make vegetable spiralizer noodles.  There are other spiralizer brands but I find the three blade Paderno to not be cost prohibitive (shop online), and it has lasted through many uses.

Vegetable noodles is a neat trick for spaghetti sides, be it scampi or marinara sauce based.  Recipes abound on the internet using spiralizer vegetable noodles, but a few of my favorites are:

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Blog: Alzheimer's, Blog: Clinical Trials-Diet/Environment/Disease, Blog: Leaky Gut, Blog: Microbiome

Alzheimer’s Diet, Microbiome, & Bio-marker Predictors

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SUMMARY:  Learn the latest on Alzheimer’s Diet, Microbiome, & Bio-marker Predictors.  Such is welcome news as the latest Alzheimer’s Facts & Figures show that over 5 million Americans are living with Alzheimer’s, including an estimated 200,000 under the age of 65.  

By 2050, the number of people age 65 and older with Alzheimer’s disease may nearly triple, from 5 million to as many as 16 million.  Truly, Alzheimer’s is one of the diseases most feared in my talks; it is the sixth-leading cause of death in the United States.   The estimate is that by age 64, one in 8 will have Alzheimer’s.  That rate doubles every 5 years.  So by age 70, one in 4 will have Alzheimer’s.  And by age 75, one in 2 will have Alzheimer’s.  These stats are from a 2013  interview of Dr. Thomas Wisniewski, @ time 25:30: “Brains – The Latest Research 07/01/2013 – 08:04” (NYU Langone Medical Center Audiocast, SirusXM Dr. Radio programming), who’s lab, Dr. Thomas Wisniewski’s Lab, is one of the leading Alzheimer research labs.

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Pillar: Toxins

Ditch Antibacterials. DON’T USE AIR HAND DRYER

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The post, ANTIBACTERIALS: DEMO SAFETY OR REMOVE PER FDA, first told you about the FDA proposed rule on Dec. 16, 2013 that gave soap manufacturers one year to demonstrate that antibacterial additives are safe or to take them out of the products altogether.  The FDA rule required manufacturers to provide more “substantial data” to demonstrate the safety and effectiveness of antibacterial soaps, but it is limited since it only covers those consumer antibacterial soaps and body washes that are used with water.  

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Blog: Autism, Blog: Clinical Trials-Diet/Environment/Disease, Blog: Microbiome

Autism Microbiome Study: 2 Studies Seek Participants

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The 1st major funded Autism Microbiome Study:

“Autism Speaks Invests $2.3 Million in Research on Autism Gut-Brain Connection,“ which makes these studies the first major funded GI initiative that investigates microbiome, biological stress and  bowel  disorder treatment in children with autism.  

Clinical trials will span 3 years and are now filling if you are interested.  Please share this information on Facebook, Twitter, Pinterest… so that others can participate.  While this research might be a decade or so behind what parents know, it’s two decades ahead of our GP and many autism treatment facilities, so it’s needed, it’s important, and I’m very grateful to hear about it.

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Blog: Clinical Trials-Diet/Environment/Disease, Blog: Diabetes, Blog: IBD, Blog: Microbiome & Newborn

Microbirth: Health Ramifications associated with C-Section birth

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SUMMARY:  Learn the long term health ramifications associated with  C-Section birth.  “Microbirth” information every parent needs to view.

“Microbirth“ is a new 60 minute documentary investigating the latest scientific research about the microscopic events happening during childbirth.  As this Press Release explains, latest research is starting to indicate modern birth practices could be interfering with critical biological processes.   From the changes that occur in the human pregnant vaginal microbiome to that microbiome which actually inoculates the baby, be it via C-section or vagina birth, these  events are now showing to have associated consequences for the health of the child and  such could have life-long consequences making our children more susceptible to disease later in life:

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Blog: Cancer, Blog: Clinical Trials-Diet/Environment/Disease

Clinical Trials Lack Diversity & Microbiome = Cancer Disparity Outcomes

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Under representation of minority populations in clinical trials is a real problem, and it results in significant cancer outcome disparities for under represented groups (discussed at the bottom of this post).  What this means is that the findings of clinical trials are limited and can not necessarily be generalized among those minorities under represented or omitted in the study population.  Such subgroups are missing information on how they would respond to the trial’s treatment.  “Potential racial, ethnic and other differences in response to drugs are important to FDA’s efforts to help ensure that the safety and effectiveness of drugs are studied in all people who will use the products once they are approved.” Christine Merenda, M.P.H., R.N. , Office of Minority Health (OMH) project manager.

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Blog: Cancer, Blog: Microbiome, Whole Food

By 2030 adult young colon cancer diagnoses doubles

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SUMMARY: Learn here that adult young colon cancer diagnoses doubles by 2030.

The number of young adults (aged 20 to 34, and 35 to 49 years) with newly diagnosed colorectal cancer is anticipated to nearly double by 2030.

Worth repeating:  By 2030 adult young colon cancer diagnoses doubles

For ages 20 to 34 years, colon cancer increase is 90.0% and rectal cancer increase is 124.2% by the year 2030.

For ages 35 to 49 years, colon cancer increase is 27.7% and rectal cancer increase is 46.0% by the year 2030.

For patients under age 34, the increase is across all stages of disease: localized (confined to the colon or rectum), regional (contiguous and adjacent organ spread, such as to the lymph nodes, kidney and pelvic wall) and distant (referring to remote metastases).

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Blog: Clinical Trials-Diet/Environment/Disease, Blog: Microbiome & Newborn, Pillar: Toxins

1st Study: Low Dose BPA Perinatal Exposure & Food Intolerance

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There has been a lot of recent discussion about BPA, especially as it affects infants.  Now we see for the first time, that low dose BPA perinatal exposure is associated with food intolerance, specifically the egg white protein, at least for rats.  Remember the alternative, BPS, is even less studied and some say it is worse than BPA.

This January 2014 study, showed that BPA is in both breast milk and newborn and infant urines regardless if breastfed or formula fed. “RESULTS:  Total BPA was detected in 93 % of urine samples in this healthy infant population aged 3-15 months who were without known environmental exposure to BPA . Similarly, 75 % of the mothers’ breast milk samples had detectable concentrations of total BPA.”

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Blog: Microbiome, Blog: Microbiome & Fiber, CME_Microbiome, MICROBIOME WELLNESS PROGRAM, Pillar: Exercise, Pillar: Sleep, Wellness Vendor (Microbiome focus), Whole Food, Worthwhile Resources - Podcasts, Books...

Optimal Microbiome Diet From American Gut Data

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SUMMARY (updated Aug 2018):  Dr. Rob Knight’s talk, Saturday, October 18, 2014, listed eleven factors that optimize the gut microbiome based on the American Gut Data cautioning all is preliminary.  These are listed below along with an interesting article titled:  “Can We Eat Our Way To A Healthier Microbiome? It’s Complicated,” in which Dr. Knight and Jeff Leach (founders of crowd sourcing project “American Gut”) discuss the microbiome diet.  A KEY finding was that the more vegs consumed (30 different each week is BEST), the more diverse the microbiome, and that is thought to be associated with health and improved immune status since MANY chronic diseases (see the below Table) have changes in microbiome diversity AND composition, [Cantinean et al 2018].  A 2018 update on the American Gut data just published, [McDonald et al 2018], and it still says to eat 30 different vegs each week! This post also provides insight into what the microbiome experts are saying about translation of microbiome research into clinical practice.  And last, my synopsis of Dr. Knight’s talk is provided (see below the light bulb) along with my listing of fav microbiome researcher labs whose work is discussed in this post! Use them and PUBMED for your own disease prevention or mitigation research. Always. Stick with the evidence for answers as this blog does.

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