Category Archives: Blog: Microbiome

Fasano, FREE: Early Nutrition Influences Microbiome, Disease

SUMMARY:   Our food choices are fundamental for health.  The next Integrated Functional Medicine Grand Rounds installment with Cleveland Clinic is coming up on Tuesday, December 13, 2016. Listen, for FREE as Dr. Alessio FASANO, MD speaks on How Early Nutrition Influences Microbiome, Disease.  This is an incredible opportunity officially titled:  How Early Nutrition Influences Gut Microbiome and Metabolic Profiles in Health and Disease: Shifting From a Disease-Centered Approach to Patient-Oriented Functional Medicine.  For background, I have followed Dr. Fasano’s work for ages.  He is a leading gut inflammation light who put Celiac Disease, and Non Celiac Gluten Sensitivity, on the map in the US when all US health agencies literally told him those were “across the pond”.  When that happens, you know you are about to make a major break thru that will ruffle lots of feathers.  He persevered, and his findings will re-write the medical books.  Those findings opened the doors for what is now understood as:  Gut permeability ⇒ immune stimulation ⇒ inflammation ⇒ gut and systemic  ramifications ⇒ autoimmune and chronic disease.   Listen in to Dr. Fasano, FREE,  Early Nutrition Influences Microbiome, Disease!

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Microbiome Awareness Conversation from Seminar

SUMMARY:  Sharing more Microbiome Awareness conversation from the May 26 seminar, so that all can benefit, even those unable to attend!  Learn great microbiome support tips!  Amaze yourself with how much you actually learned and know!  Comment if I don’t touch on your thoughts; lets continue the conversation! 

Background and more on our bio

Dana Grau and I spoke at the Microbiome Awareness Seminar.  We explained what the microbiome is and included discussion of diet and lifestyle impact to the microbiome which affects its health.  70+ percent our immunity resides in the health of the microbiome and that microbial community then plays a key role in determining your health:

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Type 2 Diabetes, diet, microbiome

Summary:  Say you use to have Type 2 Diabetes.  How?  READ this study from ITALY.  Ma-Pi 2 diet for Type 2 Diabetes WORKED.  Type 2 Diabetes, diet, microbiome; the Ma-Pi 2 diet for Type 2 Diabetes is dietary modulation of microbiome.  Though this diet BEAT the current recommended diet by Italian professional societies (CTR) consider using it short term and supplementing the diet with healthy fat, wild caught fish, berries, and fermented dairy since the restriction of certain groups could lead to nutritional deficiencies especially vitamin B12 and calcium.   This study describes in pain staking detail, microbiome wise, microbiome impact.   Talk with your doctor for Ma-Pi 2 integration with therapy.  Managing the microbiome through diet is grassroots, and it works.   SAVE a friend and SHARE this post. That huge victory for Specific Carbohydrate Diet for the kids in Pittsburgh with IBD was grassroots.

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Breast microbiome and Cancer Risk Assessment tool

SUMMARY:  Recent studies challenge dogma and find that healthy breast tissue is NOT sterilafter-all. The breast seems to have its own microbiome of bacteria and such seems protective; dysbiosis (REDUCED richness and/or certain species) was associated with breast cancer.   Furthermore, healthy breast tissue had bacteria  Sphingomonas yanoikuyae (Proteobacteria), which is better known to degrade pollutants in the environment. In the cancer samples, there was little to none of S. yanoikuyae; this bacteria is able to use estradiols including 17-β estradiol, which are believed to be associated with breast cancer. The authors could not determine causality due to lack of S. yanoikuyae. Learn in this post microbiome implications for breast cancer, free online breast cancer risk assessment tools, ongoing studies personalizing cancer risk for mammogram frequency to reduce false positives, and look over a decent listing for cutting your risk for breast cancer in the first place from Prevention. Included specifically on that list is carotenoid loads which I preach about, including the need to consume carotenoids with the correct healthy fat so as to absorb them. LOWFAT DOES NOT ABSORB THOSE CAROTENOIDS.

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Finally, an IBD microbiome drug goes to clinical trial

Summary:  Seres Therapeutics began its Phase 1b placebo controlled clinical trial on Dec 14, 2015, for SER-287, which is the first drug aimed at the microbiome for a non-infectious, chronic condition, ulcerative colitis (UC).  This is the first IBD microbiome drug that actually targets the constituents of the microbiome. This approach treats chronic disease without suppressing  the body’s immune response. Instead, specific strains of bacteria are introduced that re-balance the billions of different types of bacteria that are in the digestive tract, which then increases immunity and manages the disease.  Instead of being immunosuppressive, this treatment targets the root cause of UC  which is gut dysbiosis, increasing immunity. SER-287 clinical trial is currently recruiting participants if you are interested; contact information is below.

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SCD thoughts given DrOz 3 Day Cleanse, Microbiome

SUMMARY:  Finally! A peek into our trillions of innards on a 3 day fruit and vegetable blitz!  Spoiler alert:  There is NOT much impact 10 days after stopping that 3 day cleanse, microbiome resulting from healing diet tenets persist!  

And that, I think, is the lesson to be learned for the healing diets such as SCD, GAPS, PALEO, AIP, WAHLs, to name a few.  Realize, the tenets of these healing diets are for everyone if you want to prevent chronic disease, not just those with chronic disease.  These protocols increase vegetables and fruits beyond what the normal Standard American Diet (SAD) yokel is consuming and adds in healthy fats so fat soluble vitamins are actually absorbed.  This is done concomitant with ditching processed foods,  including processed sugars, and other inflammatory foods.  How powerful are these tenets?  They are healing and inducing remission in messed up impoverished gut microbiomes, and some of those folks are only 80% compliant with the diet!  Nuff said.  Shouldn’t you know what these tenets are?

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Preserve & Restore Loss of Microbiome Diversity is Aggressive Preventative Medicine

SUMMARY:  Aggressive Preventative Medicine means preserving the microbiome you have and restoring any loss incurred.  See how far that thought goes with your doctor!  Diet really does work to alter the microbiome and can help to restore loss of microbiome; for example, fermented kimchi actually positively impacted metabolic syndrome factors including systolic and diastolic blood pressures, percent body fat, fasting glucose, and total cholesterol.  

⇒⇒  This post teaches how to reduce the loss of microbiome diversity and restore such – crowding out concept.

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16S rRNA challenges healthy vaginal microbiome; ferments & coconut oil rock!

SUMMARY:   Incredulously, the latest 16S rRNA research now challenges what was thought for years to be a ‘protective,’ ‘normal,’ and healthy vaginal microbiome. Our many microbiomes ideally are “inherited” and originate from our passage through the vagina, and yet it seems a ‘healthy’ and ‘normal’ vaginal microbiome has been elusive; in fact, many women have a compromised vaginal microbiome and many are asymptomatic, or perhaps not… 

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We see & perceive things differently; Neither is superior to the other

SUMMARY:  The ‘blue/black white/gold dress‘ incident is a really good way of acknowledging that people see and perceive things differently and one way is not necessarily superior to the other.  I see and appreciate this in every diet conversation I have.  I focus a lot on diet; but lifestyle tweaks help many achieve wellness when clean diet isn’t enough.  Initial microbiome studies show that stress can result in changes to the gut microbial community, specifically bacteria in the genus Lactobacillus are consistently reduced.  If clean diet isn’t enough, move onto stress busters that data shows literally reduce inflammatory markers — affirmations and meditation do such.

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IBD CAM, LDN, probiotics, SCD… & Integrative Medicine benefits gut health

SUMMARY:   IBD CAM “Probiotics, Special Diets [SCD], and Complementary Therapies:  We Know Patients Want Them, So What Do We Tell Them? was presented at the Dec. 2014  Advances in IBD conference, by Dr. Sandra Kim, MD, who noted, “SO CERTAINLY THERE IS SOME PROMISE IN AT LEAST THINKING ABOUT THIS.”  Now that’s a first!!!  At least one conventional doctor is encouraging her peers to  seriously educate themselves about IBD CAM, LDN, probiotics, SCD… and  Integrative  Medicine and to ask their patients if they are interested in them, using them and if so, what do they use, and to actively seek funding for further study of them!  And… Dr. Kim has disclosure of conflicting interests — Speaker: Nestle NutritionAbbott Laboratories and Consultant: AbbVie Pharmaceuticals!

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