“Fire in the gut is fire in the brain — Dementia, Alzheimer’s. SUMMARY: A recent study found risk of dementia in PPI users aged 75 and over. Previous studies had found that Histamine H2 antagonists (H2RAs) also have adverse cognitive impact in the elderly but the mechanism differed… it was due to anticholinergic effects; I wrote about that here. Can the heartburn drugs, dementia, Alzheimer’s risk associations be extended to younger ages?
What may be possible mechanisms? This post lists the PubMed studies finding that heartburn drugs put fire in the gut; they
SUMMARY: IBD CAM “Probiotics, Special Diets [SCD], and Complementary Therapies: We Know Patients Want Them, So What Do We Tell Them?“ was presented at the Dec. 2014 Advances in IBD conference, by Dr. Sandra Kim, MD, who noted, “SO CERTAINLY THERE IS SOME PROMISE IN AT LEAST THINKING ABOUT THIS.” Now that’s a first!!! At least one conventional doctor is encouraging her peers to seriously educate themselves about IBD CAM, LDN, probiotics, SCD… and Integrative Medicine and to ask their patients if they are interested in them, using them and if so, what do they use, and to actively seek funding for further study of them! And… Dr. Kim has disclosure of conflicting interests — Speaker: Nestle Nutrition, Abbott Laboratories and Consultant: AbbVie Pharmaceuticals!
SUMMARY: Alzheimer’s, dementia, common medications increase risk; many medications have anticholinergic effects. Three most commonly used in elderly were associated with irreversible brain impact (dementia and Alzheimer’s) and despite knowledge of the need for reducing such use, 3/4 of the study cohort had been prescribed at least one (antihistamine, acid reducers, antidepressant…).
UPDATE: This post addresses the adverse cognitive impact in the elderly of common drugs due to anticholinergic effects. There is however another mechanism for dementia and Alzheimer’s. The later post, HEARTBURN DRUGS, DEMENTIA, ALZHEIMER’S RISK FOR ALL? T2D, IS IT THE CANARY IN THE COAL MINE!?! addresses this other mechanism for dementia and Alzheimer’s for common heartburn drugs (microbiome skew and B12 (and other) nutrient depletion) for proton pump inhibitors (PPIS) and Histamine H2 antagonists (H2RAs) .
SUMMARY: Learn the latest on Alzheimer’s Diet, Microbiome, & Bio-marker Predictors. Such is welcome news as the latest Alzheimer’s Facts & Figures show that over 5 million Americans are living with Alzheimer’s, including an estimated 200,000 under the age of 65.
By 2050, the number of people age 65 and older with Alzheimer’s disease may nearly triple, from 5 million to as many as 16 million. Truly, Alzheimer’s is one of the diseases most feared in my talks; it is the sixth-leading cause of death in the United States. The estimate is that by age 64, one in 8 will have Alzheimer’s. That rate doubles every 5 years. So by age 70, one in 4 will have Alzheimer’s. And by age 75, one in 2 will have Alzheimer’s. These stats are from a 2013 interview of Dr. Thomas Wisniewski, @ time 25:30: “Brains – The Latest Research 07/01/2013 – 08:04” (NYU Langone Medical Center Audiocast, SirusXM Dr. Radio programming), who’s lab, Dr. Thomas Wisniewski’s Lab, is one of the leading Alzheimer research labs.
SUMMARY: Your gut microbiome allows you to live your life with health, wellness, and vitality, or illness and disease. Without a doubt, the MICROBIOME RULES; WHAT IS MICROBIOME?
If you haven’t already done so, you should read the post, “Diet and other things Determines Our Microbiome” to be certain you are up to date not only with what this dynamic virtual organ is, but also are cognizant of the many factors that affect the microbiome.
We can modulate this microbiome; the science is exploding daily with research that is unveiling the vast impact the gut microbiome has on all of our inner workings.
FOOD ALTERS THE MICROBIOME, with a focus here on celiac and autism, although the insight applies to all autoimmunes and chronic disease.
The post “Food Managing Autism and IBD: The Studies,” details the studies (and includes current ongoing clinical trials) showing dietary intervention (that heals the gut) can result in IBD remission or management of autism. Such occurs through optimization of the microbiome since the food we feed the microbiome, determines the gut’s community of microbiota, whose role is to affect immunity, health, wellness, and vitality. Thus, anyone looking to improve health needs to look first at optimizing the gut microbiome.